Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols
Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols
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苯基二氢咪唑喹啉催化剂中的联芳基旋转用于动力学拆分芳烷基甲醇
DOI：
10.1039/c3cy00904a
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发表时间：
2014
影响因子：
5
通讯作者：
Deng Wei-Ping
中科院分区：
文献类型：
--
作者：
Wang Zheng;Ye Jinjin;Wu Rui;Liu Yang-Zi;Fossey John S.;Cheng Jiagao;Deng Wei-Ping
Chiral nucleophilic catalysts, 6-aryl-phenyl-dihydroimidazoquinolines (PIQs), were designed, synthesised and applied to the kinetic resolution of arylalkyl carbinols with very high selectivity (S) factors (up to 530). Density functional theory calculations indicate that multiple noncovalent interactions play a key role in chiral recognition between 6-aryl-PIQ catalysts and chiral secondary alcohol substrates.
