Platelet activation and inflammatory response in patients with non-dipper hypertension
Platelet activation and inflammatory response in patients with non-dipper hypertension
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DOI：
10.1016/j.atherosclerosis.2009.09.010
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发表时间：
2010-03-01
期刊：
影响因子：
5.3
通讯作者：
Topsakal, Ramazan
中科院分区：
文献类型：
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作者：
Kaya, Mehmet Gungor;Yarlioglues, Mikail;Topsakal, Ramazan
目的：非杓型高血压患者发生动脉粥样硬化事件的风险是夜间血压比白天低10%以上的高血压患者（杓型）的3倍。血小板活化和炎症反应可能源于大多数动脉粥样硬化事件。平均血小板体积（MPV）是血小板活化的决定因素，高敏C反应蛋白（hs-CRP）是识别和监测炎症反应的最佳候选检测。我们的目的是确定与杓型和健康对照组相比，非杓型患者的MPV和hs-CRP水平是否升高。方法：研究组86例高血压病患者，40例健康体检者（男性16例，平均年龄51 ± 4）作为对照组，共126例。对所有患者进行动态血压监测。高血压患者分为两组：46例杓型患者（18例男性，平均年龄; 50 +/- 9）和40例非杓型患者（17例男性，平均年龄; 53 +/- 11）。两组的临床基线特征相似。我们测量了EDTA管中采集的血液样本中的平均血小板体积，并使用BN 2型浊度计测量了高灵敏度CRP。结果如下：非杓型患者的MPV水平高于杓型患者和血压正常者（分别为9.72 +/- 0.52 fl vs 9.38 +/- 0.33 fl和8.92 +/- 0.42 fl，p < 0.05）。非勺型患者的高敏CRP水平也显著高于勺型患者和血压正常者（分别为4.9 +/- 1.7 mg/l vs 3.8 +/- 1.5 mg/l和2.7 +/- 0.8 mg/l，p < 0.05）。非杓型高血压患者MPV与CRP水平呈显著正相关（p = 0.002，r = 0.482）。结论：非杓型高血压患者血小板活化程度和炎症反应程度均增高。与杓型患者相比，非杓型患者血小板活化和炎症反应增加可能导致动脉粥样硬化风险增加。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Non-dipper hypertensives had about three times the risk of atherosclerotic events than hypertensives whose blood pressure was > 10% lower at night compared to daytime (dippers). Platelet activation and inflammatory response may derive from most atherosclerotic events. Mean platelet volume (MPV) is a determinant of platelet activation and high sensitive C-reactive protein (hs-CRP) is the best candidate assay to identify and monitor the inflammatory response. We aimed to determine whether MPV and hs-CRP levels are elevated in non-dipper patients compared to dippers and healthy controls. In addition, we tried to find out if MPV and CRP are related to each other or not in non-dipper hypertensives.Method: The total 126 patients study group included 86 patients with hypertension and 40 healthy subjects (16 male, mean age; 51 +/- 4) as control. Ambulatory blood pressure monitoring was performed for all patients. Hypertensive patients were divided into two groups; 46 dipper patients (18 male, mean age; 50 +/- 9) and 40 non-dipper patients (17 male, mean age; 53 +/- 11). Clinical baseline characteristics were similar between groups. We measured mean platelet volume in a blood sample collected in EDTA tubes and high-sensitive CRP was measured by using BN2 model nephlometer. Results: Non-dipper patients demonstrated higher levels of MPV compared to dippers and normotensives (9.72 +/- 0.52 fl vs 9.38 +/- 0.33 fl and 8.92 +/- 0.42 fl, p < 0.05, respectively). High-sensitive CRP levels were also significantly higher in non-dippers compared to dippers and normotensives (4.9 +/- 1.7 mg/l vs 3.8 +/- 1.5 mg/l and 2.7 +/- 0.8 mg/l, p < 0.05, respectively). There was significant positive correlation between MPV and CRP levels (p = 0.002, r = 0.482) in non-dipper hypertensives.Conclusion: Our results suggest that patients with non-dipping tend to have increased platelet activation and inflammatory response. Increased platelet activation and inflammatory response could contribute to increase the atherosclerotic risk in non-dipper patients compared to dippers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.