Association between consumption of edible seaweeds and newly diagnosed non-alcohol fatty liver disease: The TCLSIH Cohort Study
Association between consumption of edible seaweeds and newly diagnosed non-alcohol fatty liver disease: The TCLSIH Cohort Study
复制标题
食用海藻与新诊断的非酒精性脂肪肝之间的关联：TCLSIH 队列研究
DOI：
10.1111/liv.14655
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发表时间：
2021-02-01
影响因子：
6.7
通讯作者：
Niu, Kaijun
中科院分区：
文献类型：
--
作者：
Li, Huiping;Gu, Yeqing;Niu, Kaijun
背景与目的海藻富含抗氧化剂和抗炎活性，对非酒精性脂肪性肝病(NAFLD)有益。然而，海藻摄入是否与NAFLD相关尚不清楚。我们在一个大规模的成人人群中调查了食用海藻与新诊断的非酒精性脂肪肝的关系。根据肝脏超声和饮酒结果诊断NAFLD。饮食信息使用经过验证和标准化的100项食物频率调查问卷进行评估。多因素Logistic回归分析海藻摄入量与NAFLD的关系。结果新诊断NAFLD患病率为20.1%。在调整了社会人口学特征、生活方式因素和其他饮食摄入量后，新诊断的NAFLD在海藻摄入量方面的多变量调整优势比(95%可信区间)几乎从未为1.00(参考)，1次/周为1.03(0.93，1.15)(P为趋势和.001)。分层分析提示肥胖状态对NAFLD有潜在的影响，非肥胖者和肥胖者在极端四分位数上的优势比(95%可信区间)分别为0.77(0.66，0.91)和1.02(0.79，1.33)。结论海藻摄入与NAFLD呈负相关，尤其是在非肥胖者。
Background & aims Seaweeds are rich sources of anti-oxidants and anti-inflammatory properties, which are beneficial to non-alcoholic fatty liver disease (NAFLD). However, whether seaweed consumption is associated with NAFLD is unknown. We investigated the association of seaweed consumption with newly diagnosed NAFLD in a large-scale adult population.Methods This cross-sectional study involved 24 572 participants aged over 18 years. NAFLD was diagnosed by results of liver ultrasonography and alcohol intake. Dietary information was assessed using a validated and standardized 100-item food frequency questionnaire. Multivariate logistic analysis was used to evaluate the association between seaweed consumption and NAFLD.Results The prevalence of newly diagnosed NAFLD was 20.1%. After adjustment for sociodemographic characteristics, lifestyle factors, and other dietary intakes, the multivariable adjusted odds ratios (95% confidence intervals) of newly diagnosed NAFLD across seaweed consumption were 1.00 (reference) for almost never, 1.03 (0.93, 1.15) for 1 times/wk (P for trend < .001). Stratified analyses suggested a potential effect modification by obesity status; the odds ratios (95% confidence intervals) across extreme quartiles was 0.77 (0.66, 0.91) in non-obese participants and 1.02 (0.79, 1.33) in obese participants (P for interaction < .001).Conclusion Seaweed consumption is negatively associated with NAFLD, especially in non-obese participants.