Decrease in red cell distribution width as a useful predictor of success after catheter ablation for atrial fibrillation: a retrospective multi-center study-猫眼课题宝

DOI：

10.1007/s00380-021-01891-2

发表时间：

2021-08

期刊：

Heart and Vessels

影响因子：

1.5

通讯作者：

中科院分区：

医学4区

文献类型：

作者：

I. Yoshimoto;Koichi Inoue;N. Oketani;H. Ichiki;M. Okada;N. Tanaka;Y. Hirao;T. Oka;Koj Tanaka;S. Harada;T. Onishi;Y. Koyama;A. Okamura;K. Iwakura;K. Fujii;M. Miyata;M. Ohishi

据报道，红细胞分布宽度(RDW)与心血管事件有关，包括房颤(AF)。我们调查了RDW值是否与房颤导管消融的结果有关。这项多中心的回顾性研究包括501例房颤患者(239例阵发性房颤、196例持续性房颤和66例长期持续性房颤)，这些患者在2017年3月至2018年5月期间接受了首次房颤消融。分别于术前、术后1~3个月评估RDW值。根据术后1年内房颤复发情况分为复发组107例(21.4%)和无复发组394例(78.6%)，空白期3个月。两组患者术前RDW值差异无统计学意义(p= 0.37)。复发组消融后RDW值无明显变化(13.55-13.60%，p= 0.37)，而无复发组RDW值显著降低(13.64-13.37%，p&lt； 0.001)。多变量COX比例风险回归分析显示，术后RDW的改变(ΔRDW)与房颤复发独立相关(危险比2.00，95%可信区间1.42-2.76，p&lt； 0.001)。受试者工作特征曲线分析显示，Δ的RDW临界值− 为0.1%时，预测房颤复发的c统计量为0.65。消融后消融期RDW的降低独立预测房颤消融1年的成功率。

Red cell distribution width (RDW) is reportedly associated with cardiovascular events, including atrial fibrillation (AF). We investigated whether the RDW values were associated with the outcomes of catheter ablation for AF. This retrospective multicenter study included 501 patients with AF (239 paroxysmal AF cases, 196 persistent AF cases, and 66 long-standing persistent AF cases) who underwent initial AF ablation between March 2017 and May 2018. The RDW values were evaluated before and at 1–3 months after the procedure. The patients were stratified based on the recurrence of AF within 1 year after the index procedure with a blanking period of 3 months into recurrence group (107 patients, 21.4%) and no-recurrence group (394 patients, 78.6%). There were no significant differences in preoperative RDW values between the groups (p= 0.37). The RDW value did not change significantly after the ablation in the recurrence group (13.55–13.60%,p= 0.37), although it decreased significantly in the no-recurrence group (13.64–13.37%,p< 0.001). Multivariate Cox proportional hazards regression analyses revealed that a postoperative change in RDW (ΔRDW) was independently associated with AF recurrence (hazard ratio 2.00, 95% confidence interval 1.42–2.76,p< 0.001). Receiver operating characteristic curve analysis revealed that a ΔRDW cut-off value of − 0.1% provided a c-statistic of 0.65 for predicting AF recurrence. Decrease in RDW during the blanking period after ablation independently predicted the 1-year success of AF ablation.

Decrease in red cell distribution width as a useful predictor of success after catheter ablation for atrial fibrillation: a retrospective multi-center study

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