Use of angiotensin II receptor blockers in animal models of atherosclerosis
Use of angiotensin II receptor blockers in animal models of atherosclerosis
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DOI：
10.1016/s0895-7061(01)02274-9
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发表时间：
2002-01-01
影响因子：
3.2
通讯作者：
Ferrario, CM
中科院分区：
文献类型：
--
作者：
Ferrario, CM
长期以来被认为是终末期血管疾病的独立危险因素，高血压和动脉粥样硬化可能通过它们对血管内皮功能障碍的影响密切相关，这是由肾素-血管紧张素系统（RAS）介导的，血管紧张素II是一种有效的血管收缩剂和RAS的主要活性肽，也可以产生与动脉粥样硬化相关的血管壁结构变化。RAS在动脉粥样硬化发病机制中的作用得到了一些证据的支持，包括动脉粥样硬化动脉壁中血管紧张素转换酶（ACE）和血管紧张素H的存在和上调。本文综述了最近的研究表明，给食蟹猴服用血管紧张素H型1受体阻滞剂（ARB）氯沙坦和奥美沙坦美多索米可以防止饮食性高脂血症的进展。由于这些作用是在不显著改变血压或血浆胆固醇水平的情况下实现的，因此表明血管紧张素II受体阻滞剂治疗的这些新作用可能会扩展这类药物在预防人类血管疾病方面的治疗范围。(C) 2002年中国高血压杂志
Long considered independent risk factors for end-stage vascular disease, hypertension and atherosclerosis may be intimately linked through their effects on vascular endothelial dysfunction, which are mediated by the renin-angiotensin system (RAS), Angiotensin II, a potent vasoconstrictor and the principal active peptide of the RAS, can also produce structural changes in the vessel wall associated with atherosclerosis. The role of RAS in the pathogenesis of atherosclerosis is supported by several lines of evidence, including the presence and upregulation of angiotensin-converting enzyme (ACE) and angiotensin H in the walls of atherosclerotic arteries. This article reviews recent research showing that administration of the angio-tensin H type 1-receptor blocking agents (ARB) losartan and olmesartan medoxomil to cynomolgus monkeys with diet-induced hyperlipidemia prevents the progression of atherosclerosis. Since these effects have been achieved without altering blood pressure or plasma cholesterol levels significantly, it is suggested that these novel effects of angiotensin II receptor blocker treatment may extend the therapeutic profile of this class of agents in the prevention of human vascular disease. (C) 2002 American Journal of Hypertension, Ltd.