nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
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DOI：
10.1038/ng883
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发表时间：
2002-06-01
期刊：
影响因子：
30.8
通讯作者：
Malicki, J
中科院分区：
文献类型：
--
作者：
Wei, XY;Malicki, J
细胞的分层组织是许多神经元结构的共同结构特征。斑马鱼基因Nagie oko(NOK)的突变会导致视网膜结构的严重破坏，表明该基因在神经元模式中起着关键作用。我们发现NOK编码一种膜相关的鸟苷酸激酶家族支架蛋白。NOK定位于视网膜神经上皮和感光细胞层的连接复合体附近。马赛克分析表明，NOK视网膜花纹表型不是细胞自主的。我们认为，NOK在有丝分裂后神经元构型中的作用是通过神经上皮细胞介导的，并且对于引导神经元在视网膜板层中到达正确的目的地是必要的。
A layered organization of cells is a common architectural feature of many neuronal formations. Mutations of the zebrafish gene nagie oko (nok) produce a severe disruption of retinal architecture, indicating a key role for this locus in neuronal patterning. We show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein. Nok localizes to the vicinity of junctional complexes in retinal neuroepithelium and in the photoreceptor cell layer. Mosaic analysis indicates that the nok retinal patterning phenotype is not cell-autonomous. We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae.