Reorientation of the Golgi apparatus and the microtubule organizing center: is it a means to polarize cell-mediated cytotoxicity?
Reorientation of the Golgi apparatus and the microtubule organizing center: is it a means to polarize cell-mediated cytotoxicity?
复制标题
高尔基体和微管组织中心的重新定位：它是极化细胞介导的细胞毒性的一种手段吗？
DOI：
10.1007/978-1-4684-8326-0_7
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发表时间：
1985
影响因子：
--
通讯作者：
Singer,SJ
中科院分区：
文献类型：
--
作者：
Dennert,G;Kupfer,A;Anderson,CG;Singer,SJ
Cell-mediated cytolysis is one of the central mechanisms of immune defense and has therefore attracted much attention. The recent availability of cloned cell lines with cytolytic activity1,2had been instrumental in understanding some of the events that lead to target cell lysis. Using negative staining and thin sectioning electronmicroscopy with clones of natural killer cells (NK) and specific H-2 restricted cytotoxic T cells (TK), we have shown that the effector cells secrete tubular structures that are inserted into target cell membranes, presumably leading to target cell destruction3,4. Previous studies by others pointed to the importance of an intact secretory system in the killer cell and the potential participation of granules in the cytolytic reaction. It was therefore hypothesized that target cell binding triggers the onset of secretion of cytolytic components from the killer ce115,6.
