Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice
Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice
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DOI：
10.1016/j.exger.2005.11.007
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发表时间：
2006-02-01
影响因子：
3.9
通讯作者：
Higuchi, K
中科院分区：
文献类型：
--
作者：
Yan, J;Fujii, K;Higuchi, K
SAMPI品系是加速衰老和严重老年性淀粉样变性的小鼠模型。我们确定了补充辅酶Q10（CoQ 10）是否可以减缓SAMP 1小鼠的衰老及其在衰老中的潜在作用。在SAMP 1小鼠中，CoQ 10和CoQ 9的血浆浓度随着年龄的增长而下降，但在SAMR 1小鼠中则没有。补充减少辅酶Q10（CoQH（2），250 mg/kg/天）一周增加血浆辅酶Q10浓度，同时血浆辅酶Q9浓度降低。在两个系列的实验中，终身补充辅酶QH 2降低了10至14个月，7至15个月和17个月龄的衰老分级评分。在第二系列实验中，与对照组相比，雌性小鼠的体重从2月龄增加到10月龄。终生补充辅酶QH 2不会延长或缩短寿命，也不会改变小鼠老年淀粉样蛋白（AApoAII）沉积率或癌症发病率。在第二系列实验中，尿液中8-羟基脱氧鸟苷的水平并不随年龄或长期补充辅酶QH而变化（2）。SAMPI小鼠尿液中丙烯醛（ACR）-赖氨酸加合物的水平随着年龄的增长而显著增加;然而，辅酶QH（2）没有影响。因此，终身膳食补充辅酶QH（2）降低了中年SAMPI小鼠的衰老程度。(c)2005年爱思唯尔公司All rights reserved.
The SAMPI strain is a mouse model for accelerated senescence and severe senile amyloidosis. We determined whether supplementation with coenzyme Q10 (CoQ10) could decelerate aging in SAMP1 mice and its potential role in aging. Plasma concentrations of CoQ10 and CoQ9 decreased with age in SAMP1 but not in SAMR1 mice. Supplementation with reduced CoQ10 (CoQH(2), 250 mg/kg/day) for one week increased plasma CoQ10 concentrations, with an accompanying decrease in plasma CoQ9 concentrations. In two series of experiments, lifelong supplementation with CoQH2 decreased the senescence grading scores from 10 to 14 months, 7 to 15 months, and at 17 months of age. The body weight of female mice increased from 2 to 10 months of age versus controls in the second series of experiments. Lifelong CoQH2 supplementation did not prolong or shorten the lifespan, nor did it alter the murine senile amyloid (AApoAII) deposition rate or cancer incidence. In the second series of experiments, urinary levels of 8-hydroxydeoxyguanosine did not change with age or long-term supplementation with CoQH(2).Urinary levels of acrolein (ACR)-lysine adduct increased significantly with age in SAMPI mice; however, CoQH(2) had no effect. Thus, lifelong dietary supplementation with CoQH(2) decreased the degree of senescence in middle-aged SAMPI mice. (c) 2005 Elsevier Inc. All rights reserved.