Efficiency of oxidative phosphorylation in liver mitochondria is decreased in a rat model of peritoneal carcinosis
Efficiency of oxidative phosphorylation in liver mitochondria is decreased in a rat model of peritoneal carcinosis
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DOI：
10.1016/j.jhep.2010.08.012
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发表时间：
2011-02-01
影响因子：
25.7
通讯作者：
Couet, Charles
中科院分区：
文献类型：
--
作者：
Dumas, Jean-Francois;Goupille, Caroline;Couet, Charles
背景与目的：癌症恶病质是一个以厌食和高代谢引起的能量负平衡为特征的动态过程。导致高代谢的机制尚未完全阐明。本研究探讨了效率的氧化磷酸化和能量消耗从大鼠分离的癌恶病质诱导腹膜癌（PC）。方法：PC产生的癌细胞（PROb）在BDIX大鼠腹腔注射。结果：与对照组大鼠相比，PC组大鼠肝线粒体氧化磷酸化效率降低（-26%），能量消耗增加（+22%）。增加的能量消耗与较高的心磷脂含量有关（+55%，p
Background & Aims: Cancer cachexia is a dynamic process characterized by a negative energy balance induced by anorexia and hypermetabolism. The mechanisms leading to hypermetabolism are not totally elucidated. This study examines the efficiency of oxidative phosphorylation and energy wasting in liver mitochondria isolated from rats with cancer cachexia induced by peritoneal carcinosis (PC).Methods: PC was generated by an intraperitoneal injection of cancer cells (PROb) in BDIX rats. The efficiency of oxidative phosphorylation and energy wasting as well as the role played by reactive oxygen species (ROS) and cardiolipin (mitochondria] inner membrane phospholipid) in these processes were assessed in liver mitochondria of PC and pair-fed control rats.Results: The efficiency of oxidative phosphorylation decreased (-26%) while energy wasting increased (+22%) in liver mitochondria from PC compared to control rats. The increased energy wasting was associated with a higher cardiolipin content (+55%, p