Pre-clinical evaluation of therapies to prevent or treat bone non-union: a systematic review protocol.
Pre-clinical evaluation of therapies to prevent or treat bone non-union: a systematic review protocol.
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DOI：
10.1186/s13643-015-0148-6
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发表时间：
2015-11-12
影响因子：
3.7
通讯作者：
Penn-Barwell JG
中科院分区：
文献类型：
--
作者：
Stewart SK;Bennett PM;Stapley SA;Dretzke J;Bem D;Penn-Barwell JG
骨折骨不连是骨科人群发病的主要原因。尽管如此，骨不连的最佳治疗仍不清楚，仍然是一个重大的临床挑战。在动物模型中的研究仍在继续，试图确定有效的临床治疗方法。拟议的系统性综述将在动物模型中评价目前骨不连的治疗方法，以确定可能成功转化为临床治疗的方法。系统性综述的方法将符合标准指南。将询问临床前研究的所有潜在来源，并与该领域的专家一起编写检索策略。将由两名审查员进行数据提取，以尽量减少偏倚。由于研究之间可能存在异质性，分析将主要是定性的。然而，如果研究亚组存在同质性，则将进行定量合成。将使用偏倚风险工具进行质量评估。到目前为止，尽管目前正在进行大量的临床前研究，但还没有一个系统的评价来解决动物模型中的骨不连治疗。本方案详细描述并概述了此类审查的方法和依据。本文的在线版本（doi：10.1186/s13643-015-0148-6）包含补充材料，可供授权用户使用。
Non-union of fractured bone is a major cause of morbidity in the orthopaedic population. Despite this, optimal management of non-union is still unclear and remains a significant clinical challenge. Research continues in animal models in an attempt to identify an effective clinical treatment. The proposed systematic review will evaluate current therapies of bone non-union in animal models, in order to identify those that may translate successfully to clinical therapies. The methodology for the systematic review will be in accordance with standard guidelines. All potential sources for pre-clinical studies will be interrogated and the search strategy written in conjunction with a specialist in this field. Data extraction will be conducted by two reviewers to minimise bias. Analysis will be predominantly qualitative because of the heterogeneity that is likely to exist between the studies. However, quantitative synthesis will be performed where homogeneity in a sub-group of studies exists. Quality assessment will be undertaken utilising a risk of bias tool. To date, there has not been a systematic review addressing bone non-union therapies in animal models despite the plethora of pre-clinical research currently being undertaken. This protocol details and outlines the methodology and justification for such a review. The online version of this article (doi:10.1186/s13643-015-0148-6) contains supplementary material, which is available to authorized users.