Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice.
Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice.
复制标题
DOI：
10.1002/jbmr.1894
复制
发表时间：
2013-07
影响因子：
6.2
通讯作者：
Tetradis, Sotirios
中科院分区：
文献类型：
--
作者：
Kang, Ben;Cheong, Simon;Chaichanasakul, Thawinee;Bezouglaia, Olga;Atti, Elisa;Dry, Sarah M.;Pirih, Flavia Q.;Aghaloo, Tara L.;Tetradis, Sotirios
Osteonecrosis of the jaw (ONJ) is a well-recognized complication of antiresorptive medications, such as bisphosphonates (BPs). Although ONJ is most common after tooth extractions in patients receiving high dose BPs, many patients do not experience oral trauma. Animal models utilizing tooth extractions and high BP doses recapitulate several clinical, radiographic and histologic findings of ONJ. We and others have reported on rat models of ONJ utilizing experimental dental disease in the absence of tooth extraction. These models emphasize the importance of dental infection/inflammation for ONJ development. Here, we extend our original report in the rat, and present a mouse model of ONJ in the presence of dental disease. Mice were injected with high dose zoledronic acid and pulpal exposure of mandibular molars was performed to induce periapical disease. After 8 weeks, quantitative and qualitative radiographic and histologic analyses of mouse mandibles were executed. Periapical lesions were larger in vehicle- vs. BP treated mice. Importantly, radiographic features resembling clinical ONJ, including thickening of the lamina dura, periosteal bone deposition and increased trabecular density, were seen in the drilled site of BP treated animals. Histologically, osteonecrosis, periosteal thickening, periosteal bone apposition, epithelial migration and bone exposure were present in the BP treated animals in the presence of periapical disease. No difference in TRAP+ cell numbers was observed, but round, detached, and removed from the bone surface cells were present in BP animals. Although 88% of the BP animals showed areas of osteonecrosis in the dental disease site, only 33% developed bone exposure, suggesting that osteonecrosis precedes bone exposure. Our data further emphasize the importance of dental disease in ONJ development, provide qualitative and quantitative measures of ONJ, and present a novel mouse ONJ model in the absence of tooth extraction that should be useful in further exploring ONJ pathophysiological mechanisms.
登录
查看更多内容
DOI：
10.1016/j.tripleo.2007.01.040
发表时间：
2007-08-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Bianch, Silvio Diego;Scoletta, Matteo;Mozzati, Marco
通讯作者：
Mozzati, Marco
影响因子：
45.3
作者：
Coleman, RE;Major, P;Cook, R
通讯作者：
Cook, R
影响因子：
3.4
作者：
Elad, Sharon;Gomori, Moshe J.;Yarom, Noam
通讯作者：
Yarom, Noam
DOI：
10.1016/j.tripleo.2007.08.040
发表时间：
2008-03-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Bedogni, Alberto;Blandamura, Stella;Nocini, Pier Francesco
通讯作者：
Nocini, Pier Francesco
影响因子：
2.2
作者：
Ali-Erdem, Mehmet;Burak-Cankaya, Abdulkadir;Korhan-Oral, Cuneyt
通讯作者：
Korhan-Oral, Cuneyt