A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria
A PET study of 5-HT1A receptors at different phases of the menstrual cycle in women with premenstrual dysphoria
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DOI：
10.1016/j.pscychresns.2006.05.002
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发表时间：
2006-12-01
影响因子：
2.3
通讯作者：
Nordstrom, Anna-Lena
中科院分区：
文献类型：
--
作者：
Jovanovic, Hristina;Cerin, Asta;Nordstrom, Anna-Lena
经前焦虑症（PMDD）的原因在很大程度上尚不清楚。据推测，正常的卵巢功能触发了大脑内与PMDD相关的生化事件，5-羟色胺起着重要作用。在本研究中，正电子发射断层扫描（PET）和[羰基-C-11]WAY-100635被用来检查5-羟色胺5-HT 1A受体在对照组的妇女和一组妇女PMDD。每例受试者进行两次PET检查，一次在排卵前（卵泡期），一次在排卵后（黄体期）。每个受试者的月经周期都通过卵巢超声检查以及血液和尿液中的激素水平来确定。在6个感兴趣的区域中测量5-HT 1A结合电位，并根据简化的参考组织模型计算。在中缝核，5-HT 1A结合电位的变化从卵泡到黄体期的月经周期在无症状的对照。在患有PMDD的女性中，观察到的阶段之间的变化显着较小。结果与先前报道的5-HT 1A受体介导的影响，表明不同的PMDD和对照组之间的Escherichia coli反应的挑战研究是一致的。这项研究主要提供了新的支持，在体内，PMDD的妇女的肾上腺素能失调。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The cause of premenstrual dysphoric disorder (PMDD) is largely unknown. It has been hypothesized that normal ovarian function triggers PMDD-related biochemical events within the brain and that serotonin plays an important role. In the present study, positron emission tomography (PET) and [carbonyl-C-11]WAY-100635 were used to examine serotonin 5-HT1A receptors in a control group of women and in a group of women with PMDD. Two PET examinations were performed in each subject, one before (follicular phase) and one after ovulation (luteal phase). Each subject's menstrual cycle was confirmed by ultrasonography of the ovaries as well as with hormone levels in blood and urine. The 5-HT1A binding potential was measured in six regions of interest and calculated according to the simplified reference tissue model. In the raphe nuclei, the 5-HT1A binding potential changed from the follicular to the luteal phase of the menstrual cycle in asymptomatic controls. In women with PMDD, the observed change between phases was significantly smaller. The results are in concordance with previously reported challenge studies of 5-HT1A receptor-mediated effects indicating different serotonergic responses between women with PMDD and controls. The study principally provides new support, in vivo, for a serotonergic dysregulation in women with PMDD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.