Catalytic enantioselective amination of enolsilanes using C2-symmetric copper(II) complexes as chiral Lewis acids.
Catalytic enantioselective amination of enolsilanes using C2-symmetric copper(II) complexes as chiral Lewis acids.
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DOI：
10.1002/chin.199949060
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发表时间：
1999-07
期刊：
影响因子：
5.2
通讯作者：
David A. Evans;Douglas S. Johnson
中科院分区：
文献类型：
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作者：
David A. Evans;Douglas S. Johnson
[分子式：见文][Cu(S，S)-t-Bu-box](OTf)2(1)催化烯醇烷与偶氮二羧酸衍生物的对映选择性胺化反应。在大于95% ee的条件下加入到偶氮亚胺中的芳基酮、酰基吡罗和硫酯的异构纯烯醇烷。使用酒精添加剂是实现催化剂周转的关键。
[formula: see text] [Cu(S,S)-t-Bu-box](OTf)2 (1) catalyzes the enantioselective amination of enolsilanes with azodicarboxylate derivatives. Isomerically pure enolsilanes of aryl ketones, acylpyrroles, and thioesters added to the azo-imide in greater than 95% ee. The use of an alcohol additive was critical to achieving catalyst turnover.