Aptamer-functionalized superporous hydrogels for sequestration and release of growth factors regulated via molecular recognition
Aptamer-functionalized superporous hydrogels for sequestration and release of growth factors regulated via molecular recognition
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DOI：
10.1016/j.biomaterials.2014.06.001
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发表时间：
2014-09-01
期刊：
影响因子：
14
通讯作者：
Wang, Yong
中科院分区：
文献类型：
--
作者：
Battig, Mark R.;Huang, Yike;Wang, Yong
虽然高效生物制剂的发现导致了各种人类疾病的有希望的治疗方法的发展，但如果使用不当，生物制剂可能会造成严重的毒性。因此，为了安全有效地递送生物制剂，合成聚合物系统已经付出了巨大的努力。然而，聚合物递送系统的应用往往受到反应条件苛刻、药物隔离效率低、药物释放调控困难等问题的限制。本研究旨在开发一种具有水凝胶和适体的超多孔材料体系来克服这些挑战。结果表明，由于超孔结构和适配体的存在，超孔水凝胶能够瞬间完全隔离大量的生长因子。此外，隔离和装载过程不涉及任何苛刻的条件。生长因子的释放动力学可以通过改变适配体的结合亲和力或使用触发效应来进行分子调节。因此，本研究提出了一种有前途的超多孔材料，用于输送高效的生物制剂，如临床应用的生长因子。(C) 2014 Elsevier Ltd.版权所有。
While the discovery of highly potent biologics has led to the development of promising therapies for various human diseases, biologics can cause severe toxicity if delivered inappropriately. Thus, great efforts have been made to synthesize polymeric systems for safe and efficient delivery of biologics. However, the application of polymeric delivery systems is often limited by problems such as harsh reaction conditions, low drug sequestration efficiency, and difficult drug release regulation. This study was aimed at developing a superporous material system with a hydrogel and an aptamer to overcome these challenges. The results have shown that the superporous hydrogel is capable of instantaneously and fully sequestering a large amount of growth factors, owing to the presence of superporous architectures and aptamers. Moreover, the sequestering and loading procedure does not involve any harsh conditions. The release kinetics of growth factors can be molecularly modulated by either changing the binding affinity of the aptamer or by using a triggering effector. Therefore, this study presents a promising superporous material for the delivery of highly potent biologics such as growth factors for clinical applications. (C) 2014 Elsevier Ltd. All rights reserved.