Seizures induce phase shifts of rat circadian rhythms
Seizures induce phase shifts of rat circadian rhythms
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DOI：
10.1016/s0006-8993(01)02780-9
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发表时间：
2001-09-21
期刊：
影响因子：
2.9
通讯作者：
Bertram, EH
中科院分区：
文献类型：
--
作者：
Quigg, M;Straume, M;Bertram, EH
理论基础：癫痫发作可能会改变神经内分泌周期。光脉冲引起昼夜节律中的相移。使用海马区点燃的大鼠来确保最大的临床表达，我们确定癫痫发作是否同样会引起相移。方法：在连续3周的实验中，我们用腹膜内放射性遥测仪监测大鼠(n=21)的昼夜温度节律。在不同的昼夜节律阶段用海马电刺激触发癫痫发作。根据发作前和发作后的CRT计算优化的、误差最小的相移。诱发癫痫以CRT为参照(t(Max)=00：00，24小时昼夜节律周期)。结果：相移(个体反应=57)在整个昼夜周期中是不同的。在00：00到06：00之间，相移并没有形成清晰的相变曲线，而是特别不同。结论：本研究表明，电诱导的惊厥以一种相位依赖的方式诱导CRT的提前和延迟，但其模式与典型的光诱导相移不同。昼夜节律紊乱可能与癫痫相关的一些内源性周期改变有关。(C)2001 Elsevier Science B.V.保留所有权利。
Rationale: Epileptic seizures may alter neuroendocrinological cycles. Light pulses induce phase shifts in circadian rhythms. Using hippocampal-kindled rats to ensure maximal clinical expression, we determined if seizures likewise induce phase shifts. Methods: We monitored the circadian rhythm of temperature (CRT) with intraperitoneal radiotelemetry in rats (n = 21) isolated from time cues and light for 3-week trials. Seizures were triggered with hippocampal electrical stimulation at different circadian phases. Optimized, least-error phase shifts were calculated from preictal and postictal CRTs. Induced seizures were referenced to CRT (t(max)=00:00, 24-h circadian cycle). Results: Phase shifts (individual responses=57) differed across the circadian cycle. Rather than forming a clear phase-response curve, phase shifts were especially variable between 00:00 and 06:00 h. Conclusions: This study demonstrates that electrically-induced seizures induce advances and delays in CRT in a phase-dependent fashion but in a pattern different from typical light-induced phase shifts. Disorders of circadian regulation may contribute to some of the altered endogenous cycles associated with epilepsy. (C) 2001 Elsevier Science B.V. All rights reserved.