Head and neck tumor cell radiation response occurs in the presence of IGF1.
Head and neck tumor cell radiation response occurs in the presence of IGF1.
复制标题
DOI：
10.1177/0022034510388037
复制
发表时间：
2011-03
影响因子：
7.6
通讯作者：
Limesand KH
中科院分区：
文献类型：
--
作者：
Victory K;Burd R;Fribley A;Sittadjody S;Arnett D;Klein RR;Limesand KH
头颈部癌症的放射治疗会对唾液腺产生严重的继发性副作用。我们以前证明，IGF 1的管理保存或恢复放射后的唾液腺功能。基于这些发现，我们建议研究IGF 1对人头颈癌细胞的作用。经放射治疗的头颈部肿瘤细胞具有肿瘤细胞存活率的显著降低，如通过MTT和结晶紫测定所测量的，与IGF 1预处理无关。同时接受放射+IGF 1治疗的头颈部鳞状细胞癌细胞异种移植物也表现出显著的肿瘤生长延迟;然而，与接受放射治疗的异种移植物相比，生长速率升高。相比之下，放射治疗后给予IGF 1对肿瘤异种移植物的生长速率没有影响。这些数据的分析表明，局部交付可能需要同步治疗，以防止放射治疗的继发性副作用，而治疗后给予IGF 1可以考虑恢复唾液功能。
Radiation therapy for head and neck cancer results in severe secondary side-effects in salivary glands. We previously demonstrated that the administration of IGF1 preserves or restores salivary gland function following radiation. Based on these findings, we propose to study the effect of IGF1 on human head and neck carcinoma cells. Head and neck tumor cells treated with radiation have significant reductions in tumor cell survival, as measured by MTT and crystal violet assays, regardless of IGF1 pre-treatment. Head and neck squamous carcinoma cell xenografts treated with concurrent radiation+IGF1 also exhibit significant tumor growth delay; however, growth rates are elevated compared with those in irradiated xenografts. In contrast, administration of IGF1 after radiation treatment has no effect on tumor xenograft growth rates. Analysis of these data suggests that localized delivery may be required for concurrent therapy to prevent secondary side-effects of radiotherapy, while post-therapy administration of IGF1 could be considered for the restoration of salivary function.
登录
查看更多内容
影响因子：
4.8
作者：
Fribley, Andrew M.;Evenchik, Benjamin;Wang, Cun-Yu
通讯作者：
Wang, Cun-Yu
影响因子：
5.3
作者：
Limesand, Kirsten H.;Schwertfeger, Kathryn L.;Anderson, Steven M.
通讯作者：
Anderson, Steven M.
DOI：
10.1016/j.ijrobp.2010.03.035
发表时间：
2010-10-01
影响因子：
7
作者：
Limesand, Kirsten H.;Avila, Jennifer L.;Klein, Rob R.
通讯作者：
Klein, Rob R.
影响因子：
5.8
作者：
Johansson, Mattias;Mckay, James D.;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf
影响因子：
3.7
作者：
Limesand, Kirsten H.;Said, Sherif;Anderson, Steven M.
通讯作者：
Anderson, Steven M.