Construction of smartphone-adapted signal visualization platform for dual-mode detection of H2S based on integrated metal-organic framework nanoprobes.
Construction of smartphone-adapted signal visualization platform for dual-mode detection of H2S based on integrated metal-organic framework nanoprobes.
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DOI：
10.1016/j.talanta.2023.125517
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发表时间：
2023-12
期刊：
影响因子：
6.1
通讯作者：
Xingxing Meng;Jing Wang;Zhen Yang;Zhiguo Liu;Zongrui Zhang;Shuijian He;Chuanping Li
中科院分区：
文献类型：
--
作者：
Xingxing Meng;Jing Wang;Zhen Yang;Zhiguo Liu;Zongrui Zhang;Shuijian He;Chuanping Li
硫化氢(H_2S)是一种有毒污染物，对多种生理过程都有很大影响。由于各种病理生理作用和环境污染问题，有必要构建和开发简单、便携的监测传感器来精确检测硫化氢。在此，我们通过将比色和光热成像分析集成到基于金属-有机骨架的芯片(ZIF-8/Cu)中，开发了一种适合智能手机的双模检测平台。由于ZIF-8的纳米限制效应，在检测硫化氢的过程中可以原位形成小尺寸的等离子体CuS，使芯片具有良好的光热性能。通过构建适合智能手机的光热成像仪，基于金属-有机骨架的芯片可以实现对硫化氢的便携式光热成像分析。此外，由于形成的CuS是一种良好的过氧化物酶样纳米酶，该芯片还可以用于触发酶催化3，3‘，5，5’-四甲基联苯胺(TMB)-H_2O_2的显色反应，从而提供了另一种使用智能手机App的比色传感模式。在这个智能手机适配的可视化平台中，便携式化学传感器可以在一个电极上同时实现两种检测模式，为准确检测硫化氢提供了一条新的途径，避免了检测过程中的假阳性或阴性错误。此外，利用时域有限差分(FDTD)仿真方法，探讨了等离子体激元效应和空间电磁场分布等深层次机理，为双模可视化平台具有良好的传感性能提供了可能的原因。这项工作为硫化氢可视化筛选中的精准、便携、智能传感平台的建设提供了新的视角。
Hydrogen sulfide (H2S) is a toxic contaminant and has great influence on many physiological processes. Due to various pathophysiological roles and environmental pollution problems, it is necessary to construct and develop simple and portable monitoring sensors for the precise detection of H2S. Herein, we developed a smartphone-adapted dual-mode detection platform by integrating the colorimetric and photothermal imaging analysis into a metal-organic framework-based chip (ZIF-8/Cu). Due to the nanoconfinement effect of ZIF-8, small-sized plasmonic CuS could be in-situ formed during the detection procedure of H2S and endowed the chips with excellent photothermal properties. By constructing a smartphone-adapted photothermal imager, the metal-organic framework-based chip could achieve a portable photothermal imaging analysis of H2S. Moreover, as the formed CuS was a good peroxidase-like nanozyme, the chips could also be used to trigger the enzymic catalytic reaction toward the chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine (TMB)-H2O2, thus providing another colorimetric sensing mode by using a smartphone App. In this smartphone-adapted visualization platform, the portable chemosensors could simultaneously achieve double detection modes at one electrode, which provided a new pathway for the accurate detection of H2S and circumvented the false-positive or negative errors during the detection process. Besides, by using the finite difference time domain (FDTD) simulation method, the in-depth mechanism, including the plasmonic effect and spatial electromagnetic field distribution, was explored to provide a possible reason for the excellent sensing performance of the dual-mode visualization platform. This work provides a new insight into the construction of the accurate, portable and smart sensing platform in the visual screening of H2S.