Applications of Infrared and Raman Microspectroscopy of Cells and Tissue in Medical Diagnostics: Present Status and Future Promises
Applications of Infrared and Raman Microspectroscopy of Cells and Tissue in Medical Diagnostics: Present Status and Future Promises
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DOI：
10.1155/2012/848360
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Laver, Nora
中科院分区：
文献类型：
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作者：
Diem, Max;Miljkovic, Milos;Laver, Nora
本文总结了过去十五年来将振动（拉曼和红外）光谱应用于医学诊断和细胞生物学问题所取得的进展。在此期间，许多研究小组已经验证了振动谱的巨大信息量；事实上，基因组、蛋白质组和代谢组信息可以通过解码观察到的振动光谱来推断。高功率计算机工作站和先进的数据分析算法的可用性极大地帮助了该解码过程。此外，用于快速收集拉曼和红外显微光谱数据的商业仪器使得仅基于光谱数据的图像收集变得实用。该领域的进步体现在振动生物和生物医学领域已建立的和新的研究小组提交的出版物数量和质量的稳步提高。
This paper summarizes the progress achieved over the past fifteen years in applying vibrational (Raman and IR) spectroscopy to problems of medical diagnostics and cellular biology. During this time, a number of research groups have verified the enormous information content of vibrational spectra; in fact, genomic, proteomic, and metabolomic information can be deduced by decoding the observed vibrational spectra. This decoding process is aided enormously by the availability of high-power computer workstations and advanced algorithms for data analysis. Furthermore, commercial instrumentation for the fast collection of both Raman and infrared microspectral data has rendered practical the collection of images based solely on spectral data. The progress in the field has been manifested by a steady increase in the number and quality of publications submitted by established and new research groups in vibrational biological and biomedical arenas.