Improving oral delivery.
Improving oral delivery.
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DOI：
10.1007/978-3-642-00477-3_12
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Wirth, Michael
中科院分区：
文献类型：
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作者：
Gabor, Franz;Fillafer, Christian;Wirth, Michael
据估计，90%的药物是口服制剂，由于对患者，制药行业和医疗保健系统的良好优势，其市场份额仍在增加。然而，考虑到药物的物理化学要求和生理条件等生物制药问题，口服给药是最具挑战性的途径之一。认识到在胃肠道环境中的溶解度、渗透性和停留时间是关键参数，可以调节药物及其递送系统的不同特性，例如大小、pH、密度、扩散、溶胀、粘附、降解和渗透性，以改善口服递送。未来的发展将集中在进一步改善患者的依从性以及通过口服途径给药生物技术药物的可行性。
It is estimated that 90% of all medicines are oral formulations and their market share is still increasing, due to sound advantages for the patient, the pharmaceutical industry and healthcare systems. Considering biopharmaceutical issues such as physicochemical requirements of the drug and physiological conditions, however, oral delivery is one of the most challenging routes. Recognising solubility, permeability and residence time in the gastrointestinal milieu as key parameters, different characteristics of drugs and their delivery systems such as size, pH, density, diffusion, swelling, adhesion, degradation and permeability can be adjusted to improve oral delivery. Future developments will focus on further improvement in patient compliance as well as the feasibility of administering biotech drugs via the oral route.