P 048 – Garcinia kola – African ethno medication with anti-atherosclerotic effects?
P 048 – Garcinia kola – African ethno medication with anti-atherosclerotic effects?
复制标题
P 048 â 藤黄果 â 具有抗动脉粥样硬化作用的非洲民族药物？
DOI：
10.1016/j.freeradbiomed.2017.04.133
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发表时间：
2017
影响因子：
7.4
通讯作者：
Peter K
中科院分区：
文献类型：
--
作者：
Wallert M;Heise J;Chen Y-C;Kluge S;Schmölz L;Schubert M;Searle AK;Koeberle A;Galli F;Werz O;Birringer O;Lorkowski S;Peter K
藤黄是非洲民族药物中用来治疗各种疾病的植物。抗炎作用是这种植物所描述的几种有益特性之一。我们推测，藤黄酸(GA)作为从藤黄属植物中分离出来的一种植物化学物质，可能与这些作用有关。因此，我们研究了赤霉素对脂多糖激活的小鼠巨噬细胞的炎症反应和炎症性疾病动脉粥样硬化的阻断作用。我们发现，GA显著抑制了脂多糖诱导的iNOS和COX2的表达上调以及相应的信号分子一氧化氮、血栓烷和前列腺素的形成。此外，GA(1 mg/kg，i.p.)影响高脂西式饮食喂养的ApoE-/-小鼠主动脉根部形成的动脉粥样硬化斑块的成分，但不影响其大小。总之，在GA处理下，通过增加胶原含量和缩小坏死核尺寸，斑块的稳定性得到了改善。基于这些数据，我们预测GA阻止炎症反应，并在动脉粥样硬化斑块的形成中发挥关键作用，特别是影响稳定性的程度。如果GA的抗动脉粥样硬化特性得到进一步研究的支持，该化合物是一种很有前途的治疗动脉粥样硬化及其并发症的新型先导分子。
The plant Garcinia kola is used in African ethno medicine to treat various diseases. Anti-inflammatory effects are one of the several beneficial properties described for this plant. We hypothesized that garcinoic acid (GA), as one of the phytochemicals isolated fromGarcinia kola, is responsible for these effects. Therefore, we investigated the capacity of GA to block the inflammatory response in LPS-activated murine macrophages and the inflammatory disease atherosclerosis. We found that the LPS-induced upregulation of the expression of iNos and Cox2 and the formation of respective signaling molecules nitric oxide, thromboxanes and prostaglandins was significantly diminished by GA. Further, application of GA (1 mg/kg, i.p.) affected the composition, but not the size of developed atherosclerotic plaques in aortic roots of ApoE-/-mice fed with high-fat Western-type diet. In brief, stability of the plaques was improved by increased collagen content and smaller necrotic core size under GA treatment. Based on these data we predict that GA blocks inflammatory response and plays a pivotal role in the formation of atherosclerotic plaques, in particular, affecting the degree of stability. If the proposed anti-atherosclerotic properties of GA are supported by further studies, this compound is a promising new therapeutic lead molecule against atherosclerosis and its complications.