One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients
One year pre-post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients
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DOI：
10.1016/j.bbi.2007.04.002
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发表时间：
2007-11-01
影响因子：
15.1
通讯作者：
Patel, Kamala D.
中科院分区：
文献类型：
--
作者：
Carlson, Linda E.;Speca, Michael;Patel, Kamala D.
目标.本研究调查了参与正念减压（MBSR）计划对早期乳腺癌和前列腺癌患者的生活质量（QL）、压力症状、情绪和内分泌、免疫和自主参数的持续影响。49名乳腺癌患者和10名前列腺癌患者参加了为期8周的MBSR计划，该计划包括放松，冥想，温和的瑜伽和日常家庭练习。在干预前和干预后以及6个月和12个月随访时评估人口统计学和健康行为、QL、情绪、应激症状、唾液皮质醇水平、免疫细胞计数、细胞内细胞因子产生、血压（BP）和心率（HR）。分别对59、51、47和41名患者在干预前和干预后以及6个月和12个月随访时进行了评估，尽管并非所有参与者都提供了每个时间点的所有结局数据。线性混合模型显示，在随访期间，压力的总体症状得到了显着改善。在随访过程中，皮质醇水平系统性下降。一年中的免疫模式支持Thl（促炎性）细胞因子的持续减少。从干预前到干预后，收缩压（SBP）降低，HR与自我报告的应激症状呈正相关。正念减压疗法的参与与生活质量的提高、压力症状的减少、皮质醇和免疫模式的改变（与压力和情绪障碍的减少一致）以及血压的降低有关。这些试点数据代表了对正念减压疗法项目参与与一系列潜在重要生物标志物之间长期关系的初步调查。版权所有（C）2007 Elsevier Inc. All rights reserved.
Objectives. This study investigated the ongoing effects of participation in a mindfulness-based stress reduction (MBSR) program on quality of life (QL), symptoms of stress, mood and endocrine, immune and autonomic parameters in early stage breast and prostate cancer patients.Methods. Forty-nine patients with breast cancer and 10 with prostate cancer enrolled in an eight-week MBSR program that incorporated relaxation, meditation, gentle yoga and daily home practice. Demographic and health behaviors, QL, mood, stress symptoms, salivary cortisol levels, immune cell counts, intracellular cytokine production, blood pressure (BP) and heart rate (HR) were assessed pre- and post-intervention, and at 6- and 12-month follow-up.Results. Fifty-nine, 51, 47 and 41 patients were assessed pre- and post-intervention and at 6- and 12-month follow-up, respectively, although not all participants provided data on all outcomes at each time point. Linear mixed modeling showed significant improvements in overall symptoms of stress which were maintained over the follow-up period. Cortisol levels decreased systematically over the course of the follow-up. Immune patterns over the year supported a continued reduction in Thl (pro-inflaffimatory) cytokines. Systolic blood pressure (SBP) decreased from pre- to post-intervention and HR was positively associated with self-reported symptoms of stress.Conclusions. MBSR program participation was associated with enhanced quality of life and decreased stress symptoms, altered cortisol and immune patterns consistent with less stress and mood disturbance, and decreased blood pressure. These pilot data represent a preliminary investigation of the longer-term relationships between MBSR program participation and a range of potentially important biomarkers. Crown copyright (C) 2007 Published by Elsevier Inc. All rights reserved.