Comparison of Ginsenosides Rg1 and Rb1 for Their Effects on Improving Scopolamine-induced Learning and Memory Impairment in Mice
Comparison of Ginsenosides Rg1 and Rb1 for Their Effects on Improving Scopolamine-induced Learning and Memory Impairment in Mice
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DOI：
10.1002/ptr.3130
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发表时间：
2010-12-01
影响因子：
7.2
通讯作者：
Xu, Chang-Jiang
中科院分区：
文献类型：
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作者：
Wang, Qiong;Sun, Li-Hua;Xu, Chang-Jiang
Rg 1和Rid是人参的两种主要活性化合物，可促进学习和记忆。本研究旨在比较Rg 1和Rb 1对东莨菪碱诱导的痴呆小鼠模型的促智作用。给小鼠腹腔注射Rg 1和Rb 1 6和12 mg/kg，连续7 d，采用跳台被动回避（SD）和Morris水迷宫（MWM）实验评价其作用，并在SD和MWM实验后测定海马乙酰胆碱酯酶（AChE）活性、乙酰胆碱（ACh）含量和5-羟色胺（5-HT）含量。结果表明Rg 1和Rb 1对痴呆小鼠的认知功能有改善作用。Rg 1在MWM中对逃避获得的影响强于Rb 1。Rg 1和Rb 1均能增加海马ACh水平，但Rg 1抑制AChE活性，而Rb 1对AChE活性无影响。Rg 1和Rb 1均能抑制东莨菪碱引起的5-HT含量的降低，但Rb 1的作用强于同剂量的Rg 1。这些结果表明，多次给予Rg 1和Rb 1对改善东莨菪碱诱导的记忆缺陷有效。Rg 1似乎比Rb 1更有效地改善获得障碍，并且两种皂苷可能通过不同的机制起作用。版权所有（C）2010约翰威利父子有限公司
Rg1 and Rid are two major active compounds of ginseng that facilitate learning and memory. The present study aimed to compare the nootropic effects of Rg1 and Rb1 in a scopolamine induced dementia mice model. After 6 and 12 mg/kg of Rg1 and Rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (SD) and the Morris water maze (MWM) tests, the acetylcholinesterase (AChE) activity, acetylcholine (ACh) content and serotonin (5-HT) level in the hippocampus were analysed after SD and MWM tests. The results showed that Rg1 and Rb1 ameliorated cognition-deficiency in mice with dementia. Rg1 showed stronger effects than Rb1 on escape acquisition in MWM. Both Rg1 and Rb1 increased ACh levels in the hippocampus, but Rg1 inhibited AChE activity while Rb1 had no effect on AChE activity. Both Rg1 and Rb1 inhibited the decrease of 5-HT induced by scopolamine, but Rb1 was more active than the same dose of Rg1. These results demonstrate that multiple administrations of Rg1 and Rb1 are effective in improving memory deficiency induced by scopolamine. Rg1 appears to be more potent than Rb1 in improving acquisition impairment, and the two ginsenosides may act through different mechanisms. Copyright (C) 2010 John Wiley & Sons, Ltd.