Physics-Based Simulation to Enable Ultrasound Monitoring of HIFU Ablation: An MRI Validation.
Physics-Based Simulation to Enable Ultrasound Monitoring of HIFU Ablation: An MRI Validation.
复制标题
基于物理的模拟可对 HIFU 消融进行超声监测：MRI 验证。
DOI：
10.1007/978-3-030-00937
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Audigier, C.
中科院分区：
文献类型：
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作者：
Audigier, C.
高强度聚焦超声(HIFU)用于非侵入性消融病变组织，但可靠、实时的热监测是确保手术安全有效的关键。我们提出了一种监测方法，将术中超声(US)和基于物理的模拟相结合，实现对温度分布的实时评估。在消融过程中，使用外部US传感器监测由于温度上升而引起的声学特性的变化。然后使用基于物理的HIFU仿真模型来生成高时间和空间分辨率的3D温度图。我们的方法利用现有的HIFU系统和外部低成本且与MR兼容的US传感器，从而使其能够与黄金标准的临床体温监测方法MR温度计进行验证。我们在硅胶中证明了该方法的可行性，进行了敏感性分析，并使用临床HIFU系统对体模数据进行了实验验证。实验结果令人满意：四次实验的平均温度误差小于。
High intensity focused ultrasound (HIFU) is used to ablate pathological tissue non-invasively, but reliable and real-time thermal monitoring is crucial to ensure a safe and effective procedure. It can be provided by MRI, which is an expensive and cumbersome modality.We propose a monitoring method that enables real-time assessment of temperature distribution by combining intra-operative ultrasound (US) with physics-based simulation. During the ablation, changes in acoustic properties due to rising temperature are monitored using an external US sensor. A physics-based HIFU simulation model is then used to generate 3D temperature maps at high temporal and spatial resolutions. Our method leverages current HIFU systems with external low-cost and MR-compatible US sensors, thus allowing its validation against MR thermometry, the gold-standard clinical temperature monitoring method.We demonstratedin silicothe method feasibility, performed sensitivity analysis and showed experimentally its applicability on phantom data using a clinical HIFU system. Promising results were obtained: a mean temperature error smaller thanwas found in four experiments.