Nerve sprouting and sudden cardiac death
Nerve sprouting and sudden cardiac death
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DOI：
10.1161/01.res.86.7.816
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发表时间：
2000-04-14
影响因子：
20.1
通讯作者：
Chen, PS
中科院分区：
文献类型：
--
作者：
Cao, JM;Chen, LS;Chen, PS
导致慢性心肌梗死（MI）患者发生心源性猝死（SCD）的因素尚不完全清楚。本研究检验了这样的假设：增强交感神经再生（神经萌芽）会增加慢性 MI 中室性心动过速 (VT)、心室颤动 (VF) 和 SCD 的可能性。在患有 MI 和完全房室 (AV) 传导阻滞的狗中，我们通过向左侧星状神经节注入神经生长因子 (NGF) 来诱导心脏交感神经萌芽（实验组，n=9）。另外 6 只患有 MI 和完全房室传导阻滞但未输注 NGF 的狗作为对照 (n=6)。免疫细胞化学染色显示实验组的交感神经萌发程度比对照组更大。 MI 后，所有狗均表现出自发性 VT，持续 5.8+/-2.0 天（1 期 VT）。术后 13.1+/-6.0 天再次出现自发性 VT（2 期 VT）。实验组 2 期 VT 频率（2.0+/-2.0/d）比对照组（0.2+/-0.2/d）高 10 倍，P
The factors that contribute to the occurrence of sudden cardiac death (SCD) in patients with chronic myocardial infarction (MI) are not entirely clear. The present study tests the hypothesis that augmented sympathetic nerve regeneration (nerve sprouting) increases the probability of ventricular tachycardia (VT), ventricular fibrillation (VF), and SCD in chronic MI. In dogs with MI and complete atrioventricular (AV) block, we induced cardiac sympathetic nerve sprouting by infusing nerve growth factor (NGF) to the left stellate ganglion (experimental group, n=9). Another 6 dogs with MI and complete AV block but without NGF infusion served as controls (n=6). Immunocytochemical staining revealed a greater magnitude of sympathetic nerve sprouting in the experimental group than in the control group. After MI, all dogs showed spontaneous VT that persisted for 5.8+/-2.0 days (phase 1 VT). Spontaneous VT reappeared 13.1+/-6.0 days after surgery (phase 2 VT). The frequency of phase 2 VT was 10-fold higher in the experimental group (2.0+/-2.0/d) than in the control group (0.2+/-0.2/d, P