Study on depressive symptoms in patients with Mayer-Rokitansky-Kuster-Hauser syndrome: an analysis of 141 cases
Study on depressive symptoms in patients with Mayer-Rokitansky-Kuster-Hauser syndrome: an analysis of 141 cases
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Mayer-Rokitansky-Küster-Hauser综合征患者抑郁症状研究：附141例分析
DOI：
10.1186/s13023-020-01405-9
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发表时间：
2020-05-24
影响因子：
3.7
通讯作者：
Zhu, Lan
中科院分区：
文献类型：
--
作者：
Chen, Na;Song, Shuang;Zhu, Lan
背景Mayer-Rokitansky-Kuster-Hauser （MRKH）综合征是一种罕见的以子宫阴道发育不全为特征的先天性疾病。MRKH综合征的诊断通常会给患者带来相当大的情绪负担。然而，关注对患者心理影响的研究有限，质量也不理想。本研究的目的是调查中国MRKH综合征患者抑郁症状的患病率，并确定与抑郁症状相关的因素。在横断面研究中，我们招募了141例MRKH综合征患者和178例年龄匹配的健康女性作为对照组。通过患者健康问卷-9 （PHQ-9）评估抑郁症状。其他参数，如社会人口学特征、治疗史、人格特征以及对女性和后代的态度，也收集在自我管理的问卷中。结果MRKH患者组PHQ-9评分(7.0 （4.5-11.0)vs. 6.0(3.0-9.0)）、中位数和IQRs均显著高于同龄对照组（P = 0.015）。MRKH患者出现抑郁症状的比例为75.2%，达到中至重度的比例为34.0%，而对照组的比例分别为61.2%和24.2%。与其他年龄组相比，20多岁的患者在PHQ-9上的得分更高。人格特质神经质水平较高（OR 1.19 95% CI 1.11-1.28）、女性气质自我评价负面（OR 3.964, 95% CI 1.371-11.464）和性功能障碍（OR 4.81 95% CI 1.24-18.72）的患者（与无性行为的患者相比）更容易表现出抑郁症状。结论：四分之三的MRKH患者表现出抑郁症状，其中三分之一的人甚至有抑郁障碍的风险。因此，对MRKH患者进行抑郁症状筛查和适当的心理治疗非常重要。
Background Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare congenital disease characterized by uterovaginal agenesis. The diagnosis of MRKH syndrome generally leads to considerable emotional burdens on patients. However, studies focusing on the psychological influence on patients are limited and of unsatisfactory quality. The aim of this study was to investigate the prevalence of depressive symptoms in Chinese patients with MRKH syndrome and to identify the factors associated with depressive symptoms. We recruited 141 patients with MRKH syndrome and 178 age-matched healthy women as control group in this cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9). Other parameters such as sociodemographic characteristics, treatment histories, personality traits, and attitudes toward femininity and offspring, were also gathered in the self-administered questionnaire. Results The PHQ-9 score was significantly higher in MRKH patient group than the age-matched control group (7.0 (4.5-11.0) vs. 6.0 (3.0-9.0)), median and IQRs) (P = 0.015). A total of 75.2% of MRKH patients suffered from depressive symptoms, and 34.0% reached a moderate to severe level, while the proportion in the control group was 61.2 and 24.2% respectively. Compared with other age groups, patients in their 20s scored higher on the PHQ-9. Patients with higher neuroticism levels in personality traits (OR 1.19 95% CI 1.11-1.28), negative self-evaluation of femininity (OR 3.964, 95% CI 1.371-11.464) and sexual dysfunction (OR 4.81 95% CI 1.24-18.72) (compared with those having no sexual activity) were more likely to exhibit depressive symptoms. Conclusions Three-quarters of MRKH patients show depressive symptoms, and one-third of these individuals are even at risk for depressive disorders. Therefore, depressive symptom screening and proper psychotherapy in MRKH patients are of great importance.