Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans
Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans
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DOI：
10.1161/01.cir.95.1.76
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发表时间：
1997-01-07
期刊：
影响因子：
37.8
通讯作者：
Imaizumi, T
中科院分区：
文献类型：
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作者：
Tamai, O;Matsuoka, H;Imaizumi, T
背景尽管长期降脂治疗改善了人类的内皮依赖性血管舒张，但短期去除LDL本身是否改善了内皮功能障碍仍然是未知的。我们用应变式体积描记法测量了单次LDL单采前后注入乙酰胆碱的前臂血流量（ACh; 4至24 μ g/min）和硝普钠（SNP; 0.2至1.2 μ g/min）。单次LDL单采降低了总LDL（从142.2+/-15.0至32.6+/-5.0 mg/mL，P
Background Although long-term lipid-lowering therapy improves endothelium-dependent vasodilatation in humans, it remains unknown whether the short-term removal of LDL per se ameliorates endothelial dysfunction.Methods and Results To examine the effects of a single session of LDL apheresis on endothelial function in patients with hypercholesterolemia, we measured forearm blood flow (FBF) by strain-gauge plethysmography before and after single LDL apheresis while infusing acetylcholine (ACh; 4 to 24 mu g/min) and sodium nitroprusside (SNP; 0.2 to 1.2 mu g/min). The single session of LDL apheresis reduced total LDL (from 142.2+/-15.0 to 32.6+/-5.0 mg/mL, P