Chemokine patterning by glycosaminoglycans and interceptors
Chemokine patterning by glycosaminoglycans and interceptors
复制标题
DOI：
10.2741/3638
复制
发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Rot, Antal
中科院分区：
文献类型：
--
作者：
Rot, Antal
趋化因子介导白细胞从血液迁移到组织中。这一过程是由趋化因子通过其在白细胞上的同源G蛋白偶联受体结合和信号传导触发的，并且需要白细胞和内皮细胞粘附分子的参与。此外，体内趋化因子活性取决于它们与血管内皮细胞表达的“辅助”分子的相互作用。分泌的趋化因子可以通过糖胺聚糖固定在管腔和近管腔内皮细胞表面上。为了靶向它们在管腔内皮细胞表面上的呈递位点，组织来源的趋化因子必须穿过内皮细胞屏障。对于炎性趋化因子，这是通过涉及Duffy抗原的主动转运来实现的，Duffy抗原是由微静脉内皮细胞表达的“拦截物”。其他趋化因子拦截剂，特别是D 6，可以作为清除诱饵，并参与清除趋化因子。趋化因子的拦截介导的运输或消除，连同它们被糖胺聚糖固定，导致血液-组织界面和组织内的趋化因子模式化。所产生的趋化因子梯度诱导白细胞从血液中移出，并且也可能是组织内定向白细胞迁移所必需的。
Chemokines mediate leukocyte emigration from blood into tissues. This process is triggered by chemokines binding and signaling through their cognate G-protein-coupled receptors on leukocytes and requires the involvement of leukocyte and endothelial cell adhesion molecules. Additionally, in vivo chemokine activity depends on their interaction with "auxiliary" molecules expressed by the vascular endothelial cells. Secreted chemokines can be immobilized on the luminal and abluminal endothelial cell surfaces by glycosaminoglycans. In order to be targeted to their presentation sites on the luminal endothelial cell surface, the tissue-derived chemokines have to cross the endothelial cell barrier. For inflammatory chemokines this is accomplished by active transport involving Duffy antigen, an 'interceptor' expressed by venular endothelial cells. Other chemokine interceptors, D6 in particular, may act as scavenging decoys and are involved in clearance of chemokines. The interceptor-mediated transport or elimination of chemokines, together with their immobilization by glycosaminoglycans, lead to chemokine patterning at the blood-tissue interface and within tissues. The resulting chemokine gradients induce leukocyte emigration from blood and may also be necessary for directed leukocyte migration within tissues.