Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases
Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases
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DOI：
10.1016/j.atherosclerosis.2007.06.016
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发表时间：
2008-02-01
期刊：
影响因子：
5.3
通讯作者：
Xu, Xin
中科院分区：
文献类型：
--
作者：
Feng, Yan;Hong, Xiumei;Xu, Xin
背景：初潮早与成年人身体肥胖增加有关，然而，这种联系主要在年轻女性中进行研究。绝经后心血管疾病（CVD）的某些代谢危险因素的变化的影响仍存在争议，衰老是一个重要的混杂因素。目的：在一个大样本量的中国女性中，研究初潮年龄、生育年龄和绝经后年龄对CVD的身体成分和代谢危险因素的影响，该影响独立于正常的衰老过程。设计：2004-2005年，从中国安徽招募了9 097名25-64岁的妇女。从每位参与者那里获得了人体测量、身体成分、血压、血脂、空腹血糖和胰岛素，以及有关月经和生活方式信息的基于问卷的采访。结果：校正年龄和其他协变量后，初潮年龄与体脂、HOMA-IR、三酰甘油和代谢综合征组分总数呈负相关，与HDL-C呈正相关（p < 0.05）。生育年限越长，体脂含量越高，总胆固醇和高密度脂蛋白胆固醇含量越低（p < 0.05）。绝经后妇女的BMI显著低于绝经前妇女，但腹部脂肪百分比显著高于绝经前妇女，血浆甘油三酯、总胆固醇、HDL-C和LDL-C水平显著高于绝经前妇女，收缩压显著低于绝经前妇女（p < 0.05）。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Background: Early menarche is associated with increased adult body fatness, however, this association has been studied primarily in young women. The impact of changes in some metabolic risk factors of cardiovascular disease (CVD) after menopause remains controversial and ageing is an important confounder.Objectives: To investigate the effect of age at menarche, reproductive years, and years post-menopause on body composition and metabolic risk factors for CVD independent of the normal ageing process in a large sample size of Chinese women.Design: Nine thousand ninety seven women aged 25-64 were recruited from Anhui, China in 2004-2005. Anthropometric measurement, body composition, blood pressure, plasma lipids, fasting glucose and insulin, as well as a questionnaire-based interview on menstruation and lifestyle information were obtained from each participant.Results: After adjusting for age and other covariates, age at menarche was inversely associated with body fatness, HOMA-IR, triacylglycerol and the total number of metabolic syndrome components, and was positively associated with HDL-C (p < 0.05). The number of reproductive years was associated with increased body fatness, decreased total cholesterol and HDL-C (p < 0.05). Post-menopausal women had significantly lower BMI but higher abdominal fat percentage, increased plasma levels of triacylglycerol, total cholesterol, HDL-C, and LDL-C, and lower systolic blood pressure than pre-menopausal women (p < 0.05).Conclusion: Age at menarche, reproductive years, and menopause status were significantly associated with body composition, insulin sensitivity and blood lipid levels. (c) 2007 Elsevier Ireland Ltd. All rights reserved.