Concordance of endogenous cortisol and phospholipase A2 levels in gram-negative septic shock: a prospective study.
Concordance of endogenous cortisol and phospholipase A2 levels in gram-negative septic shock: a prospective study.
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革兰氏阴性败血性休克中内源性皮质醇和磷脂酶 A2 水平的一致性：一项前瞻性研究。
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发表时间：
1988
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影响因子：
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通讯作者：
C. Bombardier
中科院分区：
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作者：
P. Vadas;W. Pruzanski;E. Stefanski;J. Ruse;V. Farewell;J. McLaughlin;C. Bombardier
Lipocortins, a group of corticosteroid-induced phospholipase-inhibitory proteins, are thought to play a prominent role in the mediation of the anti-inflammatory effects of steroids. The synthesis and release of these proteins may represent a major endogenous mechanism of regulation of extracellular phospholipase A2 (PLA2) activity. Because soluble PLA2 activity has been associated with circulatory collapse in hyperphospholipasemic conditions, such as septic shock and pancreatitis, we examined the relationship between circulating PLA2 activity and adrenocortical function. In a prospective study of 10 episodes of septic shock, serum PLA2 and cortisol levels correlated significantly in all survivors (p less than 0.0001), whereas such a correlation was absent in all nonsurvivors (p less than 0.07). No significant correlation of cortisol and adrenocorticotropic hormone (ACTH), or PLA2 and ACTH, was found in any patient, suggesting that the stimulus for cortisol release arises from outside the hypothalamic-pituitary axis. These data suggest that, in human beings, the regulation of soluble PLA2 activity may be mediated by adrenocortical hormones, perhaps through the intermediary action of lipocortins.
