CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
CYTOKINES IN LACRIMAL FLUID AND BLOOD SERUM: EARLY BIOMARKERS OF AGE-RELATED MACULAR DEGENERATION
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泪液和血清中的细胞因子：年龄相关性黄斑变性的早期生物标志物
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
M. V. Ryabina
中科院分区：
文献类型：
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作者：
O. Slepova;M. V. Ryabina
本文介绍了在年龄相关性黄斑变性（AMD）的初期和中期血清和泪液中多重细胞因子检测的结果。在这些患者中检测到细胞因子谱的局部和全身紊乱的一些特征。结果提示：AMD患者早期泪液中IL-17水平升高，沿着TGF-β1水平的局部升高与全身下降失衡。中期AMD与血清和泪液中测定的大多数细胞因子（除了TGF-β1）水平的增加相关，因此表明促炎和血管生成反应的刺激，如抗炎和抗感染因子的激活。
The article presents results of multiplex cytokine assays in blood serum and lacrimal fluid at the initial and intermediate stages of age-related macular degeneration (AMD). Some features of local and sys- temic disturbances in the cytokine profile were detected in these patients. It was revealed that the initial stage of AMD was associated with elevated IL-17 levels in lacrimal fluid, along with imbalance between the local increase and systemic decrease of TGF-β1 amounts. Intermediate-stage AMD was associated with increased levels of the most cytokines assayed (except of TGF-β1) in blood serum and lacrimal fluid, thus suggesting stimulation of both pro-inflammatory and angiogenic responses, like as activation of anti-inflammatory and anti-infective factors.
影响因子：
6
作者：
Schwesinger, C;Yee, C;D'Amato, RJ
通讯作者：
D'Amato, RJ
影响因子：
4.2
作者：
Miller, DM;Espinos-Heidmann, DG;Cousins, SW
通讯作者：
Cousins, SW