[Effects of stress on allergic reaction].
[Effects of stress on allergic reaction].
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[压力对过敏反应的影响]。
DOI：
10.1248/yakushi.121.753
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Y. Ito
中科院分区：
文献类型：
--
作者：
C. Hayashi;H. Kataoka;M. Semma;Y. Ito
本研究旨在探讨应激对过敏反应的影响。本文研究了由通信盒引起的足电击（FS）应激或心理应激（PSY）对小鼠接触性超敏反应（SEP）的影响。在2，4-二硝基氟苯（DNFB）致敏后第4天，通过将抗原（DNFB）施加到小鼠的耳上来引起过敏。在急性应激实验中，DNFB致敏的小鼠暴露于FS或PSY应激后，与DNFB接触攻击2小时。急性FS应力显着抑制应激期结束后立即（DNFB-挑战后3小时），和一个显着的增强，观察到DNFB-挑战后5小时的ESTA。急性FS应激组小鼠血清皮质酮浓度在应激负荷后即刻显著高于对照组。急性PSY应激后大鼠血清皮质酮和血清皮质酮水平与对照组基本相同。急性FS应激负荷引起的应激反应的暂时性降低可能与应激产生的血清皮质酮有关，皮质酮的增加可能是增强迟发型超敏反应（delayed-type hypersensitivity）的触发因素。慢性应激实验设计暴露小鼠FS或PSY应激2小时，每天与DNFB致敏后。这些慢性压力导致小鼠体重显著下降。对慢性FS应激负荷小鼠的海马神经元的暂时性降低作用与急性FS应激负荷小鼠相似。相反，在激发后24 h和48 h，未观察到显著增强的延迟期（晚期）。虽然体重的变化表明小鼠受到慢性PSY应激的影响，但与急性PSY应激负荷的情况一样，暴露于慢性PSY应激的小鼠的体重与对照组没有显著差异。慢性PSY应激和抑郁症之间的相关性仍有待确定。
The purpose of the present study was to investigate the effects of stress on allergic reaction. We studied changes in the contact hypersensitivity reaction (CHR) of mice exposed to foot shock (FS) stress or psychological (PSY) stress induced by the communication box. CHR was elicited by applying antigen (2,4-dinitrofluorobenzene, DNFB) to the ear of the mice at 4 days after DNFB sensitization. In acute stress experiments, DNFB-sensitized mice were exposed for 2 h to FS or PSY stress after contact challenge with DNFB. Acute FS stress significantly inhibited CHR immediately after the end of the stress period (3 h after DNFB-challenge), and a significant enhancement of the CHR was observed at 5 h after DNFB-challenge. The concentration of the serum corticosterone level of the mice exposed to acute FS stress significantly increased compared to the control mice, immediately after stress loading. Both CHR and serum corticosterone levels after acute PSY stress loading were almost the same as those of the control groups. The temporary decrease of the inflammatory reaction at CHR caused by acute FS stress loading may have been correlated with serum corticosterone produced by the stress, and the increase of corticosterone may act as a trigger of enhancement of the CHR (delayed-type hypersensitivity). Chronic stress experiments were designed to expose mice to FS or PSY stress 2 h daily after sensitization with DNFB. These chronic stresses caused a significant reduction in the body weight of mice. The temporary decrease effect on the CHR of chronic FS stress-loaded mice was similar to the acute FS stress-loaded mice. In contrast, no significant enhancement of the CHR (late phase) at 24 h and 48 h after challenge was observed. Although the changes in body weight suggested that mice were influenced by chronic PSY stress, no significant difference from the control group for the CHR of mice exposed to chronic PSY stress was found, as in the case of acute PSY stress loading. The correlation between chronic PSY stress and CHR remains to be ascertained.