Fatigue, pain, and depression in pre-autotransplant breast cancer patients
Fatigue, pain, and depression in pre-autotransplant breast cancer patients
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DOI：
10.1046/j.1523-5394.1999.75008.x
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发表时间：
1999-09-01
期刊：
影响因子：
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通讯作者：
Kennedy, MJ
中科院分区：
文献类型：
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作者：
Gaston-Johansson, F;Fall-Dickson, JM;Kennedy, MJ
目的：本研究的目的是确定疲劳，疼痛和抑郁对乳腺癌患者的健康状况的影响谁完成了辅助化疗和单纯安排自体骨髓/外周血干细胞移植（AT）。材料和方法：一个预测，相关性设计，ii方便的127名妇女与第二，第三，和电视乳腺癌的样本被招募。该研究的背景是位于美国东部的一个城市国家癌症研究所指定的综合癌症中心。采用标准化问卷和Gandel-Johansson疼痛计（POM）测量变量。受试者在门诊完成问卷调查。疲劳和疼痛、抑郁和健康状况的多个维度之间的关系仅仅被检验。分层回归技术仅仅用于确定valance在健康状况占疲劳，疼痛，和depression.RESULTS：受试者的年龄为22至60岁（平均值= 45; SD = 7.6），主要是已婚，白色，新教徒，受过大学教育，受雇于一个专业的职位，并有平均家庭年收入等于或大于50000美元。所有受试者既往均接受过手术和化疗。91%的参与者报告疲劳视觉焦虑量表测量的疲劳。47%的参与者报告疼痛，通过Gandel-Johansson POM视觉模拟量表测量。54%的死亡参与者报告抑郁症，从轻度到重度/高。受试者报告的平均总感知健康状况评分为50.73（SD 10.79）。疲劳、疼痛和抑郁都与彼此以及总体健康状况显著相关。抑郁（P <0.001）和疼痛（P <0.01）占总健康状况变量的64%（校正R-2 = 0.60）。疲劳（P < .05）和抑郁（P < .001）占健康状况感知方差的42%（调整后的R-2 = .36）。结论：既往接受过化疗的乳腺癌女性;等待AT的inds可能会经历疲劳、疼痛、抑郁和健康状况的改变。疼痛和抑郁对女性的总体健康状况有显著影响，而抑郁和疲劳对感知的健康状况有影响。在健康状况的不同维度中，一个人对健康状况的感知与总体健康状况的相关性最强（r = .84，P < .001）。医疗保健专业人员需要了解多种症状对健康状况的影响，并提供适当的护理来缓解这些症状。
OBJECTIVES: The purpose of this study was to determine the influence of fatigue, pain, and depression on health status in breast cancer patients who had completed adjuvant chemotherapy and mere scheduled for autologous bone marrow/peripheral blood stem cell transplant (AT).MATERIALS AND METHODS: A predictive, correlational design was used, ii convenience sample of 127 women with stages II, III, and TV breast cancer was recruited. The setting was an urban National Cancer Institute-designated comprehensive cancer center located in the Eastern United States. Standardized questionnaires and the Gaston-Johansson Painometer (POM) were used to measure the variables. The subjects completed questionnaires in the outpatient clinic. Relationships between een the multiple dimensions of fatigue and pain, depression, and health status mere examined. Hierarchical regression techniques mere used to determine the valance in health status accounted for by fatigue, pain, and depression.RESULTS: The subjects were age 22 to 60 years (Mean = 45; SD = 7.6), and primarily were married, white, Protestant, college educated, employed in a professional position, and had an average yearly household income of equal to or greater than $50,000. All subjects had previously received surgery and chemotherapy. Ninety-one percent of the participants reported fatigue as measured by the Fatigue Visual Analogue Scale. Forti-seven percent of the participants reported pain as measured by the Gaston-Johansson POM visual analogue scale. Fifty-four percent of die participants reported depression, ranging from mild to severe/high. Subjects reported a mean total perceived health status rating of 50.73 (SD 10.79). Fatigue, pain, and depression were all significantly correlated to each other and to total health status. Depression (P < .001) and pain (P < .01) significantly accounted for 64% (adjusted R-2 = .60) of the variance in total health status. Fatigue (P < .05) and depression (P < .001) accounted for 42% (adjusted R-2 = .36) of the variance in the perception of health status.CONCLUSIONS: Women with breast cancer previously treated with chemotherapy;ind awaiting AT may experience fatigue, pain, depression, and alterations in health status. Pain and depression had a significant impact on a woman's total health status, whereas depression and fatigue had an influence on perceived health status. Of the different dimensions of health status, one's perceptions of health status had the strongest correlation to total health status (r = .84, P < .001). Healthcare professionals need to be aware of the effects of multiple symptoms on health status and to provide appropriate care to alleviate them.