Effects of suckling on hypothalamic LH-releasing factor and prolactin inhibiting factor, and on pituitary LH and prolactin.
Effects of suckling on hypothalamic LH-releasing factor and prolactin inhibiting factor, and on pituitary LH and prolactin.
复制标题
哺乳对下丘脑 LH 释放因子和催乳素抑制因子以及垂体 LH 和催乳素的影响。
DOI：
10.1210/endo-80-4-603
复制
发表时间：
1967
期刊：
影响因子：
4.8
通讯作者：
Joseph Meites
中科院分区：
文献类型：
--
作者：
Hiroshi Minaguchi;Joseph Meites
The effects of suckling on the hypothalamic content of luteinizing hormone-releasing factor (LRF) and on prolactin inhibiting factor (PIF), and on pituitary concentration of LH and prolactin were studied in lactating rats. On postpartum day 18, lactating mother rats were killed by guillotine. Regular cycling rats of the same strain served as controls. Anterior pituitary halves incubated with hypothalamic extract from suckled rats released significantly less LH but more prolactin into the medium than the corresponding control pituitary halves incubated with hypothalamic extract from cycling rats. Pituitary LH concentration was significantly decreased and pituitary prolac-tin was significantly increased in the suckled rats when compared with the cycling controls. Suckling also significantly reduced pituitary, ovarian and uterine weights. These observations indicate that the suckling acts on the hypothalamus to depress release of LRF and PIF, the former resulting in inhibition of pituitary LH release and the...
