Psychrophilins E-H and Versicotide C, Cyclic Peptides from the Marine-Derived Fungus Aspergillus versicolor ZLN-60
Psychrophilins E-H and Versicotide C, Cyclic Peptides from the Marine-Derived Fungus Aspergillus versicolor ZLN-60
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嗜冷素 E-H 和 Versicotide C，来自海洋源性真菌 Aspergillus versicolor ZLN-60 的环肽
DOI：
10.1021/np500469b
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发表时间：
2014-10-01
影响因子：
5.1
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Peng, Jixing;Gao, Huquan;Li, Dehai
从海洋源性真菌 Aspergillus versicolor ZLN-60 的培养物中获得了四种新的环肽，即嗜冷素 E-H (1-4)，在邻氨基苯甲酸 (ATA) 中的羧酸与吲哚部分的氮之间具有罕见的酰胺键，以及一种新的含有 ATA 的六肽，versicotide C (5)。通过结合 HRESIMS、NMR、X 射线晶体学、TDDFT ECD 计算和 Marfey 方法，阐明了包括绝对构型在内的结构。 Versicotide C (5) 是第一个含有两个邻氨基苯甲酸的天然环状六肽。化合物1-5没有细胞毒性，化合物3显示出有效的降脂作用。
Four new cyclic peptides, psychrophilins E-H (1-4), possessing a rare amide linkage between the carboxylic acid in anthranilic acid (ATA) and the nitrogen from an indole moiety, along with a new ATA-containing hexapeptide, versicotide C (5), were obtained from the culture of the marine-derived fungus Aspergillus versicolor ZLN-60. The structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, TDDFT ECD calculations, and Marfey's method. Versicotide C (5) is the first natural cyclic hexapeptide containing two anthranilic acids. Compounds 1-5 were not cytotoxic, and compound 3 showed potent lipid-lowering effects.