Vasculopathy plays an important role during the development and relapse of encapsulating peritoneal sclerosis with conventional peritoneal dialysis solutions
Vasculopathy plays an important role during the development and relapse of encapsulating peritoneal sclerosis with conventional peritoneal dialysis solutions
复制标题
DOI：
10.1093/ndt/gfaa073
复制
发表时间：
2021-08-01
影响因子：
6.1
通讯作者：
Kawanishi, Hideki
中科院分区：
文献类型：
--
作者：
Tawada, Mitsuhiro;Ito, Yasuhiko;Kawanishi, Hideki
背景：包裹性腹膜硬化（EPS）是腹膜透析（PD）治疗中一种罕见但危及生命的并发症。EPS的病因尚不清楚。腹膜受EPS影响的病理研究及其与PD溶液等临床因素的关系仍然缺乏。本研究的目的是检查EPS患者的腹膜样本，并确定腹膜病理与不同临床因素的关系。方法1993 ~ 2016年土屋总医院手术肠溶术时取腹膜标本。共纳入并分析了223例PD患者。组织用福尔马林固定，苏木精和伊红染色，马松三色染色，CD31和CD68免疫组化染色。结果对174例行肠溶术的患者进行了评价。在PD治疗期间，使用常规或ph中性低糖降解产物PD溶液。常规PD溶液组血管生成较少（P=0.013），但血管病变更严重，表现为管腔直径与血管直径之比（L/V比）较低(P
Background Encapsulating peritoneal sclerosis (EPS) is an uncommon but life-threatening complication of peritoneal dialysis (PD) therapy. The causative factors of EPS remain unclear. Pathological studies of the peritoneum affected by EPS and relationships with clinical factors including PD solutions remain lacking. The objective of this study was to examine peritoneal samples from EPS patients and to identify the associations of peritoneal pathology with different clinical factors.Methods Peritoneal specimens were obtained at the time of surgical enterolysis in Tsuchiya General Hospital from 1993 to 2016. A total of 223 PD patients were enrolled and analyzed. Tissues were fixed with formalin and processed with hematoxylin and eosin and Masson's trichrome staining, as well as immunohistochemical staining for CD31 and CD68.Results Evaluations could be made in 174 patients who received surgical enterolysis. Conventional or pH-neutral low-glucose degradation product PD solutions were utilized during PD treatment. The conventional PD solution group showed less angiogenesis (P=0.013) but more severe vasculopathy, in the form of a lower ratio of luminal diameter to vessel diameter (L/V ratio) (P