LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
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DOI：
10.1016/s1074-7613(00)80530-0
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发表时间：
1997-08-01
期刊：
影响因子：
32.4
通讯作者：
Phillips, JH
中科院分区：
文献类型：
--
作者：
Meyaard, L;Adema, GJ;Phillips, JH
在本研究中，我们描述了一种新的抑制性受体，白细胞相关的免疫球蛋白样受体-1（LAIR-1），这是组成型表达的大多数人外周血单核白细胞。LAIR-1是一种32 kDa的跨膜糖蛋白，具有单个免疫球蛋白样结构域和含有两个基于免疫受体酪氨酸的抑制基序的胞质尾区。LAIR-1在活化时募集SHP-1和SHP-2磷酸酶，并且LAIR-1抗原在自然杀伤（NK）细胞上的交联导致对NK细胞介导的细胞毒性的强烈抑制。尽管LAIR-1在结构上与人类杀伤细胞抑制性受体相关，但它似乎不识别人类白细胞抗原（HLA）I类分子，因此代表了一种新的不依赖HLA I类的NK细胞调节机制。
In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and crosslinking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.