Out-of-plane microtube arrays for drug delivery-liquid flow properties and an application to the nerve block test
Out-of-plane microtube arrays for drug delivery-liquid flow properties and an application to the nerve block test
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DOI：
10.1007/s10544-008-9259-3
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发表时间：
2009-06-01
影响因子：
2.8
通讯作者：
Ishida, Makoto
中科院分区：
文献类型：
--
作者：
Takei, Kuniharu;Kawashima, Takahiro;Ishida, Makoto
我们已经提出了使用选择性气-液-固(VLS)生长技术和微制造工艺来制备非常精细的面外二氧化硅微管阵列。在这项研究中，我们阐明了不同内径的微管的液体流动特性。我们制作的微管的壁厚为0.5微米，高度为20微米，内径为2.5微米、4.1微米、4.6微米或6.4微米。确定了流压与流过微管的液体流量之间的关系。我们还进行了神经阻断实验，用内径为4.6微米的微管向大鼠坐骨神经注入利多卡因溶液(钠通道阻滞剂)。这项成功的测试是首次报道使用微管将药物输送到大鼠的周围神经。我们的结论是，所提出的微管阵列及其制造工艺可能有助于开发药物器件。
We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor-liquid-solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 mu m in wall thickness; 20 mu m in height; and either 2.5 mu m, 4.1 mu m, 4.6 mu m, or 6.4 mu m in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6 mu m inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices.