The fate of duplicated genes: loss or new function?
The fate of duplicated genes: loss or new function?
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DOI：
10.1002/(sici)1521-1878(199810)20:10
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发表时间：
1998-10
期刊：
影响因子：
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通讯作者：
A. Wagner
中科院分区：
文献类型：
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作者：
A. Wagner
基因复制事件是新基因功能的重要来源。然而，更多的时候，重复基因可能会失去其功能，成为假基因。这两种情况的相对频率是多少：功能分化与基因丢失？考虑到大多数非中性突变是有害的，基因丢失应该远比分歧更频繁。然而，最近的一项实证研究表明，大约50%的基因重复会导致功能分化。这项研究从脊椎动物进化早期两次连续的基因组复制产生的基因家族的大小分布中推断出功能分歧的频率。这出乎意料的高频率的功能分歧的原因进行了讨论。
Gene duplication events are important sources of novel gene functions. However, more often than not, a duplicate gene may lose its function and become a pseudogene. What is the relative frequency of these two scenarios: functional divergence versus gene loss? Given that most non-neutral mutations are deleterious, gene loss should be far more frequent than divergence. However, a recent empirical study suggests that about 50% of all gene duplications will lead to functional divergence. The study infers the frequency of functional divergence from the size distribution of gene families produced by two successive genome duplications early in vertebrate evolution. Reasons for this unexpectedly high frequency of functional divergence are discussed.