Biological roles of L-carnitine in perinatal metabolism
Biological roles of L-carnitine in perinatal metabolism
复制标题
DOI：
10.1016/s0378-3782(98)00064-4
复制
发表时间：
1998-12-01
影响因子：
2.5
通讯作者：
Campos, Y
中科院分区：
文献类型：
--
作者：
Arenas, J;Rubio, JC;Campos, Y
肉毒碱通过控制脂肪酸流入线粒体，在胎儿期和新生儿期的组织能量供应中起着至关重要的作用。肉毒碱还促进丙酮酸和支链氨基酸的氧化，并有助于保护细胞免受酰基辅酶A的有害作用。肉毒碱进一步作为一个次要的抗氧化剂，有利于脂肪酸取代以前氧化损伤的膜磷脂。L-肉碱的可用性是必不可少的胎儿发育过程中潜在的胎儿成熟。左旋肉碱也是肝酮合成的发展所必需的，肝酮合成是新生儿能量代谢的中心途径。酮体抑制葡萄糖和乳酸的氧化，使这些代谢底物免于生物合成功能。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
Carnitine performs a crucial role in the energy supply of tissues during fetal life and in the neonatal period by controlling the influx of fatty acids into mitochondria. Carnitine also facilitates the oxidation of pyruvate and branched chain amino acids, and contributes to the protection of cells from the deleterious actions of acyl CoAs. Carnitine further acts as a secondary antioxidant, favouring fatty acid replacement within previously oxidatively damaged membrane phospholipids. Availability of L-carnitine is essential in the developing fetus for processes underlying fetal maturation. L-carnitine is also essential for development of hepatic ketone synthesis, a central pathway for neonatal energy metabolism Ketone bodies inhibit the oxidation of both glucose and lactate, sparing these metabolic substrates for biosynthetic functions. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.