High- sensitivity C- reactive Protein Level is an Independent Predictor of Poor Prognosis in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
High- sensitivity C- reactive Protein Level is an Independent Predictor of Poor Prognosis in Cirrhotic Patients With Spontaneous Bacterial Peritonitis
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DOI：
10.1097/mcg.0b013e3182a6cdef
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发表时间：
2014-05-01
影响因子：
2.9
通讯作者：
Lee, Hyo-Suk
中科院分区：
文献类型：
--
作者：
Cho, Yuri;Park, So Youn;Lee, Hyo-Suk
背景/目的：超敏C反应蛋白（hs-CRP）的产生可能受肝功能的影响，hs-CRP在肝硬化患者中的临床意义尚不清楚。本研究的目的是评估hs-CRP在自发性细菌性腹膜炎（SBP）患者中的临床意义。方法：我们回顾性调查了2007年至2012年336例连续接受SBP治疗的患者。结果：182例（54.2%）抗生素治疗有效，126例（37.5%）死于SBP。初始hs-CRP（比值比=1.061，P=0.016），并存肝细胞癌，和Child-Pugh（CP）评分是高住院死亡率的独立预后因素。血清hs-CRP水平也是抗生素应答率较低的独立预测因子（OR =0.916，P
Background/Aims:The production of high-sensitivity C-reactive protein (hs-CRP) may be affected by hepatic function, and the clinical importance of hs-CRP in patients with liver cirrhosis is still not clear. The aim of this study was to evaluate the clinical implications of hs-CRP in cirrhotic patients with spontaneous bacterial peritonitis (SBP).Methods:We retrospectively investigated 336 consecutive patients treated for SBP from 2007 to 2012. The relationship between serum hs-CRP and the result of the treatment was assessed.Results:A response to antibiotics was observed in 182 patients (54.2%), and 126 patients (37.5%) died of SBP. The initial hs-CRP (odds ratio=1.061, P=0.016), coexistent hepatocellular carcinoma, and Child-Pugh (CP) score were independent prognostic factors for high in-hospital mortality. Serum hs-CRP level was also an independent predictor of lower antibiotic response rate (odds ratio=0.916, P