Evo-Devo Mechanobiology: The Missing Link
Evo-Devo Mechanobiology: The Missing Link
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DOI：
10.1093/icb/icad033
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发表时间：
2023-05-16
影响因子：
2.6
通讯作者：
Nerurkar，Nandan L.
中科院分区：
文献类型：
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作者：
Loffet，Elise A.;Durel，John F.;Nerurkar，Nandan L.
虽然进化发展的现代框架（evo-devo）已经决定性地遗传，但历史分析也考虑了力学在形式进化中的重要性。随着最近的技术进步，在量化和扰动的变化，在分子和机械效应器的有机体形状的帮助下，分子和遗传线索如何调节形态发生的生物物理方面正变得越来越好的研究。因此，这是一个考虑如何通过进化作用于形态发生基础的组织规模机制以建立形态多样性的好时机。这样一个焦点将使一个领域的进化发育机械生物学，将有助于更好地阐明基因和形式之间的不透明的关系，阐明中介的物理机制。在这里，我们回顾了形状的演变是如何测量和遗传学相关，如何最近的进展已经在解剖发育组织力学，以及我们如何期望这些领域在未来的evo-devo研究合并。
While the modern framework of evolutionary development (evo-devo) has been decidedly genetic, historic analyses have also considered the importance of mechanics in the evolution of form. With the aid of recent technological advancements in both quantifying and perturbing changes in the molecular and mechanical effectors of organismal shape, how molecular and genetic cues regulate the biophysical aspects of morphogenesis is becoming increasingly well studied. As a result, this is an opportune time to consider how the tissue-scale mechanics that underlie morphogenesis are acted upon through evolution to establish morphological diversity. Such a focus will enable a field of evo-devo mechanobiology that will serve to better elucidate the opaque relations between genes and forms by articulating intermediary physical mechanisms. Here, we review how the evolution of shape is measured and related to genetics, how recent strides have been made in the dissection of developmental tissue mechanics, and how we expect these areas to coalesce in evo-devo studies in the future.