Retinoid receptors and their coregulators.
Retinoid receptors and their coregulators.
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DOI：
10.1146/annurev.pharmtox.43.100901.140301
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发表时间：
2003-11
影响因子：
12.5
通讯作者：
Li-Na Wei
中科院分区：
文献类型：
--
作者：
Li-Na Wei
类维甲酸通过结合核受体、视黄酸受体（RARs）和类维甲酸X受体（RXRs）调节基因转录。RARs和RXRs是配体激活的转录因子，用于调控ra应答基因。RARs和RXRs对基因转录的作用需要与大量的辅激活子和辅抑制子高度协调的相互作用。这篇综述的重点是我们目前对这些已知与RARs和RXRs协同作用的共调节因子的理解。这些共调节因子的作用机制开始被揭示，包括染色质的修饰和基础转录因子的募集。了解RARs和RXRs的特异性作用，以及由受体、共调节因子和其他未知因素组成的特异性转录复合物的形成，仍然是一个挑战。
Retinoids regulate gene transcription by binding to the nuclear receptors, the retinoic acid (RA) receptors (RARs), and the retinoid X receptors (RXRs). RARs and RXRs are ligand-activated transcription factors for the regulation of RA-responsive genes. The actions of RARs and RXRs on gene transcription require a highly coordinated interaction with a large number of coactivators and corepressors. This review focuses on our current understanding of these coregulators known to act in concert with RARs and RXRs. The mechanisms of action of these coregulators are beginning to be uncovered and include the modification of chromatin and the recruitment of basal transcription factors. Challenges remain to understand the specificity of action of RARs and RXRs and the formation of specific transcription complexes consisting of the receptors, coregulators, and other unknown factors.