Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone
Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone
复制标题
DOI：
10.1016/j.ijpharm.2008.03.021
复制
发表时间：
2008-07-09
影响因子：
5.8
通讯作者：
Choi, Han-Gon
中科院分区：
文献类型：
--
作者：
Kim, Jong Oh;Park, Jung Kil;Choi, Han-Gon
采用冻融法制备了含有局部抗感染药物呋喃西林（NFZ）的聚乙烯醇（PVA）/海藻酸钠（SA）水凝胶基质伤口敷料系统。将不同重量比的呋喃西林和PVA/SA混合物的水溶液均匀混合，置于培养皿中，在-20 ° C冷冻18 h并在室温下解冻6 h，连续三个循环，并评价水凝胶的溶胀比、拉伸强度、伸长率和热稳定性。此外，从该负载硝呋酮的水凝胶的药物释放，在体外蛋白吸附试验和在大鼠体内伤口愈合观察。SA浓度的增加降低了凝胶化率、最大强度和断裂伸长率，但增加了水凝胶膜的溶胀能力、弹性和热稳定性。水杨酸对呋喃西林的释放无明显影响。随着海藻酸钠比例的增加，水凝胶上蛋白质的吸附量增加，表明血液相容性降低。体内实验表明，这种水凝胶提高了大鼠人工伤口的愈合率。因此，基于PVA/SA水凝胶基质的含有呋喃西林的伤口敷料系统可能是伤口护理的新方法。(C)2008 Elsevier B. V.保留所有权利。
Polyvinyl alcohol (PVA)/sodium alginate (SA) hydrogel matrix-based wound dressing systems containing nitrofurazone (NFZ), a topical anti-infective drug, were developed using freeze-thawing method. Aqueous solutions of nitrofurazone and PVA/SA mixtures in different weight ratios were mixed homogeneously, placed in petri dishes, freezed at -20 degrees C for 18 h and thawed at room temperature for 6 h, for three consecutive cycles, and evaluated for swelling ratio, tensile strength, elongation and thermal stability of the hydrogel. Furthermore, the drug release from this nitrofurazone-loaded hydrogel, in vitro protein adsorption test and in vivo wound healing observations in rats were performed. Increased SA concentration decreased the gelation%, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of nitrofurazone. The amounts of proteins adsorbed on hydrogel were increased with increasing sodium alginate ratio, indicating the reduced blood compatibility. In vivo experiments showed that this hydrogel improved the healing rate of artificial wounds in rats. Thus, PVA/SA hydrogel matrix based wound dressing systems containing nitrofurazone could be a novel approach in wound care. (C) 2008 Elsevier B.V. All rights reserved.