Chronic blockade of angiotensin II action prevents glomerulosclerosis, but induces graft vasculopathy in experimental kidney transplantation
Chronic blockade of angiotensin II action prevents glomerulosclerosis, but induces graft vasculopathy in experimental kidney transplantation
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慢性阻断血管紧张素 II 作用可预防肾小球硬化，但在实验性肾移植中会诱发移植物血管病变
作者：
Annemieke Smit‐van Oosten;G. Navis;C. Stegeman;J. Joles;P. Klok;F. Kuipers;A. Tiebosch;H. van Goor
长期的肾素-血管紧张素系统阻断剂对多种肾脏疾病有益。本研究检查了血管紧张素转换酶抑制剂赖诺普利和血管紧张素II受体I型阻滞剂L158，809在Fisher至刘易斯大鼠慢性肾移植衰竭模型中的长期（34周）效应。在移植后10天，或在蛋白尿超过50 mg/24 h时，开始用赖诺普利或L158，809治疗同种异体移植大鼠。未处理的同种异体移植物和同系移植物作为对照。与同系移植物相比，未处理的同种异体移植物发生蛋白尿、高胆固醇血症、间质损伤和肾小球硬化。在移植后第10天开始的同种异体移植物中的赖诺普利或L158，809治疗完全防止了这一点，除了间质损伤，但这种治疗也导致血压和肾功能降低。此外，与未处理的同种异体移植大鼠相比，用赖诺普利或L158，809处理的同种异体移植物的肾动脉内膜表面积显著增加。一旦出现蛋白尿，治疗在预防肾小球硬化方面效果较差，但也引起较少的内膜扩张。因此，慢性肾素-血管紧张素系统阻断在无蛋白尿的情况下保留肾小球形态，但在实验移植中增强内膜增生并降低肾功能。鉴于这些结果，应该质疑这种治疗是否对肾移植患者长期有益。版权所有© 2001约翰威利父子有限公司。
Long‐term renin–angiotensin system blockade is beneficial in a variety of renal diseases. This study examines the long‐term (34 weeks) effects of the angiotensin‐converting enzyme inhibitor lisinopril and the angiotensin II receptor type I blocker L158,809 in the Fisher to Lewis rat model of chronic renal transplant failure. Treatment in allografted rats with lisinopril or L158,809 was initiated 10 days after transplantation, or at the time when proteinuria exceeded 50 mg/24 h. Untreated allografts and syngrafts served as controls. In contrast to syngrafts, untreated allografts developed proteinuria, hypercholesterolaemia, interstitial damage, and glomerulosclerosis. Lisinopril or L158,809 treatment in allografts starting at day 10 after transplantation completely prevented this, with the exception of interstitial damage, but this treatment also caused a reduction in blood pressure and renal function. Moreover, the intimal surface area of the renal arteries was dramatically increased in allografts treated with either lisinopril or L158,809 compared with untreated allografted rats. Treatment once proteinuria had developed was less effective in preventing glomerulosclerosis, but also caused less intimal expansion. Thus, chronic renin–angiotensin system blockade preserves glomerular morphology in the absence of proteinuria, but enhances intimal hyperplasia and reduces renal function in experimental transplantation. In view of these results, it should be questioned whether such treatment benefits renal transplant patients in the long term. Copyright © 2001 John Wiley & Sons, Ltd.
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影响因子：
8.3
作者：
BERK, BC;VEKSHTEIN, V;TSUDA, T
通讯作者：
TSUDA, T
同种异体抗原依赖性和非同种异体抗原依赖性因素都会影响慢性同种异体移植排斥。
DOI：
--
发表时间：
1995
期刊：
Transplantation.
影响因子：
--
作者：
Tullius,SG;Tilney,NL
通讯作者：
Tilney,NL
抗高血压药物治疗对自发性高血压大鼠血管平滑肌细胞肥大、超倍体和增生的不同影响。
影响因子：
20.1
作者：
Owens,GK
通讯作者：
Owens,GK
影响因子：
15.9
作者：
Niimura, F;Labosky, PA;Ichikawa, I
通讯作者：
Ichikawa, I
影响因子：
158.5
作者：
LEWIS, EJ;HUNSICKER, LG;ROHDE, RD
通讯作者：
ROHDE, RD