The nucleosome remodeling and deacetylase complex in development and disease.
The nucleosome remodeling and deacetylase complex in development and disease.
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DOI：
10.1016/j.trsl.2014.05.003
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Rauchman M
中科院分区：
文献类型：
--
作者：
Basta J;Rauchman M
核小体重塑和脱乙酰酶（NuRD）复合物是细胞中发现的主要染色质重塑复合物之一。它在调节基因转录、基因组完整性和细胞周期进程中起重要作用。通过其对这些基本细胞过程的影响，越来越多的证据表明，这种大分子复合物的活性改变可导致发育缺陷、肿瘤发生和加速衰老。最近的遗传和生物化学研究已经阐明了NuRD在修改染色质景观中的作用机制。这些进展有可能导致出生缺陷和癌症的新治疗方法。
The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the major chromatin remodeling complexes found in cells. It plays an important role in regulating gene transcription, genome integrity and cell cycle progression. Through its impact on these basic cellular processes, increasing evidence indicates that alterations in the activity of this macromolecular complex can lead to developmental defects, oncogenesis and accelerated ageing. Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer.