Enhanced thermal antinociceptive potency and anti-allodynic effects of morphine following spinal administration of endotoxin
Enhanced thermal antinociceptive potency and anti-allodynic effects of morphine following spinal administration of endotoxin
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DOI：
10.1016/s0006-8993(02)03885-4
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发表时间：
2003-01-17
期刊：
影响因子：
2.9
通讯作者：
Coderre, TJ
中科院分区：
文献类型：
--
作者：
Cahill, CM;Dray, A;Coderre, TJ
最近，描述了一种中枢炎症动物模型，其特征是脑室内（i.c.v.）给予脂多糖（LPS）后广泛的皮肤痛觉过敏和异常性疼痛。在本研究中，我们证明通过鞘内 (i.t.) 注射 LPS 的中枢给药会在大鼠中产生双侧触觉异常性疼痛和热痛觉过敏。此外，在该模型中还确定了吗啡诱导的镇痛作用。在这里，我们展示了 i.t. 增强的热镇痛功效。与对照组相比，LPS 处理的大鼠中的吗啡。鞘内注射吗啡也能有效减轻 LPS 引起的触觉异常性疼痛。 i.t. 产生的镇痛作用和抗异常性疼痛作用。皮下注射纳洛酮(1 mg·kg(-1))可完全拮抗吗啡。这项研究表明，中枢给予 LPS 后会出现热痛觉过敏和机械性异常性疼痛，并且 i.t 的抗伤害作用会增强。该模型中的吗啡。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Recently, an animal model of central inflammation characterized by widespread cutaneous hyperalgesia and allodynia following intracerebroventricualr (i.c.v.) administration of lipopolysaccharide (LPS) was described. In the present study, we demonstrate that central administration of LPS via intrathecal (i.t.) injection produces bilateral tactile allodynia and thermal hyperalgesia in the rat. Also, the effects of morphine-induced antinociception were determined in this model. Here we demonstrate enhanced thermal antinociceptive potency of i.t. morphine in LPS-treated rats compared to controls. Intrathecal morphine was also effective in alleviating the tactile allodynia induced by LPS. Both the antinociceptive and anti-allodynic effects produced by i.t. morphine were completely antagonized by pretreatment with subcutaneous naloxone (1 mg kg(-1)). This study demonstrates the presence of both heat hyperalgesia and mechanical allodynia following central administration of LPS, and an increased antinociceptive potency of i.t. morphine in this model. (C) 2002 Elsevier Science B.V. All rights reserved.