TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation.
TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation.
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DOI：
10.1093/narcan/zcac009
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发表时间：
2022-03
期刊：
影响因子：
5.1
通讯作者：
Hoffmann S
中科院分区：
文献类型：
--
作者：
Fischer M;Schwarz R;Riege K;DeCaprio JA;Hoffmann S
近年来，我们在www.TargetGeneReg.org的网络图谱使许多研究人员发现了新的生物学见解，并确定了影响p53和细胞周期的新调控机制——在癌症等疾病中经常失调的信号通路。在这里，我们提供了数据库的实质性升级，包括扩展到包括非编码基因和转录因子ΔNp63和RFX7。TargetGeneReg 2.0结合了基因表达谱和转录因子DNA结合数据，以确定每个基因对p53， ΔNp63和细胞周期信号的反应。它可用于解剖常见的细胞类型和治疗特异性效应，确定最有希望的候选药物，并验证发现。我们使用实际示例演示了增强的功能和更直观的资源布局。网址为www.TargetGeneReg.org的网络图谱包括基因表达和转录因子DNA结合数据，以确定每个基因对p53、ΔNp63和细胞周期信号的反应。
In recent years, our web-atlas at www.TargetGeneReg.org has enabled many researchers to uncover new biological insights and to identify novel regulatory mechanisms that affect p53 and the cell cycle – signaling pathways that are frequently dysregulated in diseases like cancer. Here, we provide a substantial upgrade of the database that comprises an extension to include non-coding genes and the transcription factors ΔNp63 and RFX7. TargetGeneReg 2.0 combines gene expression profiling and transcription factor DNA binding data to determine, for each gene, the response to p53, ΔNp63, and cell cycle signaling. It can be used to dissect common, cell type and treatment-specific effects, identify the most promising candidates, and validate findings. We demonstrate the increased power and more intuitive layout of the resource using realistic examples. The web-atlas at www.TargetGeneReg.org includes gene expression and transcription factor DNA binding data to determine, for each gene, the response to p53, ΔNp63, and cell cycle signaling.