SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy.
SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy.
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DOI：
10.1097/md.0000000000001344
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发表时间：
2015-10
期刊：
影响因子：
1.6
通讯作者：
Zhou WP
中科院分区：
文献类型：
--
作者：
Jiang BG;Yang Y;Liu H;Gu FM;Yang Y;Zhao LH;Yuan SX;Wang RY;Zhang J;Zhou WP
既往研究表明，细胞因子信号传导抑制因子3（SOCS 3）蛋白与肝细胞癌（HCC）的发生和进展相关，但SOCS 3基因遗传多态性与HCC的相关性尚不清楚。共有254名HCC患者和354名健康对照入组。所有HCC患者均接受部分肝切除术作为初始治疗并进行随访。SOCS3基因存在3种多态性，即rs4969170 A>G、rs8064821 C>T和rs12953258 C>A。我们的数据显示rs4969170 A>G多态性显著影响我们队列中HCC的易感性。Logistic回归分析显示，rs4969170 GG在调整混杂因素后是HCC的危险因素。rs4969170A>G多态性与肝癌患者的临床特征相关，并可预测术后无复发生存期和总生存期。rs4969170GG基因型携带者的预后比rs4969170AG和rs4969170AA基因型携带者差。SOCS3基因rs4969170A>G多态性可作为手术治疗后肝癌患者预后的预测因子。
Previous studies showed that suppressor of cytokine signaling 3 (SOCS3) protein is associated with incidence and progression of hepatocellular carcinoma (HCC); however, the association between the genetic polymorphism of SOCS3 gene and HCC remains unknown. A total of 254 HCC patients and 354 healthy controls were enrolled. All HCC patients underwent partial hepatectomy as initial treatment and were followed. Three SOCS3 gene polymorphisms, namely, rs4969170 A>G, rs8064821 C>T, and rs12953258 C>A were determined. Our data show that the rs4969170 A>G polymorphism dramatically affects the susceptibility to HCC in our cohorts. Logistic regression analyses revealed that the rs4969170 GG is a risk factor for HCC after the adjustment with confounding factors. The rs4969170A>G polymorphism is also associated with the clinical features of HCC patients and predicts the postoperative relapse-free survival and overall survival. The rs4969170GG genotype carrier had a worse prognosis than the rs4969170AG and rs4969170AA carrier. Our findings suggest that the rs4969170A>G polymorphism of SOCS3 gene may be used as a prognostic predictor for HCC patients who underwent surgical treatment.