fMRI evidence of age-related hippocampal dysfunction in feature binding in working memory
fMRI evidence of age-related hippocampal dysfunction in feature binding in working memory
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DOI：
10.1016/s0926-6410(00)00029-x
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发表时间：
2000-09-01
期刊：
影响因子：
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通讯作者：
D'Esposito, M
中科院分区：
文献类型：
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作者：
Mitchell, KJ;Johnson, MK;D'Esposito, M
对特定事件的丰富详细的记忆取决于将经验的各个特征结合在一起的过程。先前的认知行为研究表明，老年人在需要特征绑定的条件下比年轻人更困难。我们在工作记忆任务中使用功能性磁共振成像（fMRI）来识别这种与年龄相关的特征结合缺陷的神经基质。对于年轻的成年人，而不是老年人，在组合试验（记住物体及其位置）中，左前海马体的激活程度要高于被告知只记住哪些物体或只记住哪些位置发生的试验。这些结果为工作记忆中特征结合的年龄相关性海马功能障碍提供了神经影像学证据。(C)2000 Elsevier Science B.V.保留所有权利。
Richly detailed memories for particular events depend on processes that bind individual features of experience together. Previous cognitive behavioral research indicates that older adults have more difficulty than young adults in conditions requiring feature binding. We used functional magnetic resonance imaging (fMRI) during a working memory task to identify neural substrates of this age-related deficit in feature binding. For young, but not older, adults there was greater activation in left anterior hippocampus on combination trials (remember objects together with their locations) than on trials in which participants were told to remember only which objects or only which locations occurred. The results provide neuroimaging evidence for an age-related hippocampal dysfunction in feature binding in working memory. (C) 2000 Elsevier Science B.V. All rights reserved.