Stromal cell-derived factor-1 and its receptor CXCR4 in adult neurogenesis after cerebral ischemia
Stromal cell-derived factor-1 and its receptor CXCR4 in adult neurogenesis after cerebral ischemia
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DOI：
10.3233/rnn-120271
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Zhao, Chuansheng
中科院分区：
文献类型：
--
作者：
Cui, Lili;Qu, Huiling;Zhao, Chuansheng
基质细胞衍生因子-1最初被发现作为免疫细胞的化学引诱物。后来研究表明，基质细胞衍生因子-1及其特异性受体CXCR 4在发育和成熟的大脑中广泛表达。它们参与多种生理和病理过程，包括脑发育、血管生成、神经变性和神经发生。基质细胞衍生因子-1/CXCR4通过介导神经原细胞的增殖，调节新生神经元的迁移、分化以及功能整合到现有网络中，在成人神经发生中发挥特别重要的作用。中风后，脑室下区和颗粒下区的成年神经发生显著增加，受损组织释放基质细胞衍生因子-1和基质金属蛋白酶。基质细胞衍生因子-1促进成神经细胞的增殖及其向损伤区域的迁移。然而，中风后产生的大多数神经母细胞经历凋亡，只有少数分化并长期存活。基质细胞衍生因子-1和基质金属蛋白酶的相互作用可能导致不利的局部微环境减少新生神经元的存活。基质细胞衍生因子-1/基质金属蛋白酶及其下游通路可能为脑卒中的治疗提供新的靶点。
Stromal cell-derived factor-1 was originally found as a chemoattractant for immune cells. Later it was shown that stromal cell-derived factor-1 and its specific receptor CXCR4 were widely expressed in the developing and mature brains. They participate in a variety of physiological and pathological processes including brain development, angiogenesis, neurodegeneration and neurogenesis. Stromal cell-derived factor-1/CXCR4 plays a particularly important role in adult neurogenesis through mediating the proliferation of neurogenitors, regulating the migration, differentiation, as well as functional integration of newborn neurons into existing networks. After stroke, adult neurogenesis in both the subventricular zone and subgranular zone is robustly increased and stromal cell-derived factor-1 and matrix metalloproteinases are released by damaged tissue. Stromal cell-derived factor-1 promotes the proliferation of neuroblasts and their migration to injured areas. However, the majority of the neuroblasts produced after stroke undergo apoptosis and only a few differentiate and survive in the long-term. The interaction of stromal cell-derived factor-1 and matrix' metalloproteinases may contribute to the unfavorable local microenvironment diminishing the survival of newborn neurons. Stromal cell-derived factor-1/matrix metalloproteinases and their downstream pathways may provide a new target for the treatment of stroke.